PubMed Health⌕ Search

Biomedical subjects

M T Leung

Publications and source records attributed to M T Leung.

2 recordsLinked to original sources

Sentence processing deficits in two Cantonese aphasic patients.

This paper reports the performances of two Cantonese aphasics on tasks examining their sentence processing deficits. The data on sentence comprehension show that thematically noncanonical sentences, full passives, and subject-gap sentences present greater difficulty to these patients than canonical sentences, truncated passives, and object-gap sentences, respectively. These patterns are consistent with previous observations on Chinese aphasics and are expected given the structural differences between Chinese and English. In a Cantonese grammaticality judgment test, a set of structures are identified that can elicit clear judgments from normal subjects and aphasics, contrary to the claim that grammaticality judgments in Chinese are probabilistic and fragile. Most interestingly, the patients' overall performance patterns reveal a double dissociation between sentence comprehension and judgment of sentence well-formedness, suggesting that the two tasks are supported by independent processing mechanisms.

Adult↗

The effect of trifluoperazine and R 24 571 on the K+-evoked release of 5-hydroxytryptamine from superfused synaptosomes.

The effect of trifluoperazine (10 microM) and of R 24571 (0.1 and 1.0 microM) on the release of [3H]-5-HT from superfused synaptosomes from rat brain was studied. Trifluoperazine, but not R 24571, produced a rapid transient increase in the basal efflux of [3H]-5-HT. This effect may be due to the cleavage of either Ca2+ or [3H]-5-HT from binding sites on the synaptosomal membrane. In contrast to the effects on the basal efflux of [3H]-5-HT, both drugs significantly inhibited the release of [3H]-5-HT in response to K+ depolarisation. This effect of trifluoperazine did not appear to be due to the known membrane stabilising effects of the drug, but appeared more likely to be due to the calmodulin-inhibiting effect of the drug. The results of this study support the view that calmodulin may be an important intermediate linking depolarisation with transmitter release in nerve terminals.

Animals↗