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Biomedical subjects

M T Pheils

Publications and source records attributed to M T Pheils.

13 recordsLinked to original sources
PubMed1979

A pattern of local recurrence following resection of colorectal cancer.

Twenty patients (10%) developed a local recurrence following 200 consecutive curative resections for colorectal carcinoma. Analysis of the pathology of the primary tumours suggests that invasion of adjacent tissues, and lymph node involvement, were more important presection on the mucosa. The average time interval between resection and diagnosis of local recurrence was 17 months. The average survival time following diagnosis was 10 months. Nineteen out of 20 of these patients developed evidence of disseminated disease subsequent to the diagnosis of local recurrence. The most effective palliation occurred in patients in whom the local recurrence could be resected.

Colonic Neoplasms↗
PubMed1977

Hepatic metastases from colorectal carcinoma: an analysis of survival rates and histopathology.

Out of 338 patients undergoing laparotomy and resection of a primary colorectal carcinoma, 49 (14-5%) were folnd to have liver metastases. The average age was 70 years. The median period of survival was 11-4 months. The histological grade of malignancy of the primary tumour did not appear to influence the survival rate. Compared with similar tumours in patients without hepatic metastases, the primary growth showed a significantly increased incidence of venous invasion, a higher grade of malignancy, and a more frequent origin from the right colon. When the local spread of the primary tumours was investigated it was found that one-third of them had not progressed beyond Stage Dukes A or B.

Adenocarcinoma↗
PubMed1976

Colorectal carcinoma: a prospect clinicopathological study.

The clinical and pathological findings in 200 consecutive cases of colorectal carcinoma treated by surgical resection have been recorded and subjected to computer analysis. This is the initial report from a long-term prospective survey of this disease. The two most frequent presenting symptoms were altered bowel habit (51.5%) and bleeding (49.5%). Symptoms due to anaemia occurred in 16% of cases and acute obstruction in 13.5% of cases. The value of the various investigations in establishing the diagnosis is discusses. At the time of resection the disease had already reached an advanced stage in a majority of the patients. In 26% of cases it was known that complete resection of tumour tissue had not been achieved. A direct relationship between stage of spread and histological grade of malignancy was noted. The incidence of advanced stage, high histological grade and mucinous tumours was greatest in the right side of the colon. A study of early carcinomas has confirmed that many have arisen from benign epithelial neoplastic polyps. The significance of these observations is discussed.

Adenocarcinoma, Mucinous↗
PubMed1976

Closure of colostomy.

A retrospective review of 110 patients who had their colostomies closed during the period from 1963 to 1973 has been undertaken. Their average age was 64 years. Diverticular disease and colorectal cancer had been the most frequent indications for the colostomy. Wound infection occurred in 36.4% and faecal fistula in 7.3%. These complications occurred less frequently in patients who had antibiotic bowel preparation. The overall mortality rate was 4.5%. Measures to reduce the morbidity and mortality are discussed.

Adult↗
PubMed1975

Cholecystostomy for acute cholecystitis.

During the period from 1963 to 1970, 318 patients were subjected to early operation for acute cholecystitis. Cholecystostomy was performed in 25 cases (7.8 percent). Despite advanced age and associated serious illnesses, cholecystostomy was an effective and definitive method of treatment. Many of these patients are likely to succumb from intercurrent disease before they develop further stones or cholecystitis. A planned cholecystostomy may be the operation of choice for poor-risk patients with acute cholecystitis.

Acute Disease↗