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Biomedical subjects

M T Roghani

Publications and source records attributed to M T Roghani.

6 recordsLinked to original sources

Multidrug resistant neonatal sepsis in Peshawar, Pakistan.

OBJECTIVE: To investigate the spectrum of organisms causing neonatal sepsis in Peshawar, Pakistan and to assess their sensitivity to various groups of drugs. METHODS: Blood taken from newborn babies admitted to the special care baby unit at the Khyber Teaching Hospital with a clinical diagnosis of neonatal sepsis was cultured. The data obtained from October 1997 to December 2000 were analysed and the results tabulated. RESULTS: A total of 1598 blood cultures were taken; 1003 were positive (positivity rate 62.8%). Escherichia coli was the most common organism found (36.6%), followed by Staphylococcus aureus (29.5%), Pseudomonas (22.4%), Klebsiella (7.6%), and Proteus (3.8%). No group B streptococcus was grown. Listeria monocytogenes was found in one cerebrospinal fluid culture. E coli and Pseudomonas showed a high degree of resistance to commonly used antibiotics (ampicillin, augmentin, and gentamicin), a moderate degree of resistance to cephalosporin (cefotaxime, ceftzidime, and ceftrioxone), and low resistance to drugs not used for newborn babies (ofloxacin, ciprofloxacin, and enoxabid). S aureus showed a low resistance to all three groups of antibiotics. CONCLUSION: Neonatal sepsis remains one of the leading causes of neonatal admission, morbidity, and mortality in developing countries. Gram negative organisms are the major cause of neonatal sepsis in Peshawar. Such organisms have developed multidrug resistance, and management of patients infected with them is becoming a problem in developing countries.

Anti-Bacterial Agents↗

Immunization coverage in three districts of North West Frontier Province (NWFP).

AIM: This community-based study was conducted to assess the progress of Expanded Programme on Immunization (EPI) in North West Frontier Province (NWFP) of Pakistan. METHOD: In this cross sectional survey, 120 randomly selected clusters in 03 districts of NWFP were included, 2673 children in the age group 12-35 months of 2583 randomly selected families were visited. RESULTS: The results showed that 65% of children were fully immunized, but out of them only half could be verified by immunization, need of 2nd and 3rd dose and no faith in immunization were the major causes of failure of immunization programme. Moreover, mother too busy, absence of vaccinator and inconvenient place of immunization were the obstacles pointed out by the parents. CONCLUSION: This study suggests the areas where improvement can be made to achieve the real target of immunization coverage. It is concluded that despite of more than 20 years of efforts by EPI, the ultimate objectives have not been achieved.

Child, Preschool↗

Erythrocyte glucose 6 phosphate dehydrogenase deficiency and neonatal jaundice.

Four years data from Special Care Baby Unit revealed neonatal jaundice (NNJ) as the commonest cause of hospitalization (1944 cases of NNJ out of 6454 admitted neonates). Majority (47.5%) of babies with NNJ presented between 4-7 days of birth. One hundred and sixty infants with NNJ were positive for Glucose 6 Phosphate dehydrogenase (G6PD) deficiency, of whom 153 were males and 7 females. Eighty five G6PD deficient babies required exchange transfusion and 23 developed bilirubin encephalopathy (BE) of which 7 died.

Age Factors↗

A study of 123 new born infants.

This paper is based on a study of 123 new born infants selected from general wards, private nursing homes. It was found that the average weight of babies born to mothers of upper social class was more than that of middle and lower social class. The chest and head circumference of upper social class was greater than the middle and lower social class, but there was no difference in their length. It was interesting to note that the incidence of prematurity was much higher in the middle and lower social class and was the incidence of congenital anomalies.

Birth Weight↗