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M T Sanz

Publications and source records attributed to M T Sanz.

9 recordsLinked to original sources
PubMed2000

Prognostic value of the quantified expression of p185 in non-small cell lung cancer.

BACKGROUND: We sought to assess the relationship between tissue concentration of erb -b-2 or neu oncogene-encoded protein (p185(neu)) with overall survival in patients with non-small cell lung cancer. METHODS: Levels of protein p185(neu) were determined in 102 patients with the diagnosis of non-small cell lung cancer. Concentration of p185(neu) protein was determined by using enzyme immunoassay and evaluated by using several variables. The relative prognostic importance of this marker and its influence on other prognostic factors was evaluated by using the Cox regression model. RESULTS: The mean p185(neu) value in these samples was 250 +/- 200 U/mg (95% confidence interval, 210-290). This distinguished two groups within the tumoral population: those with less than 350 U/mg and those with 350 U/mg or greater (80th percentile). Multivariable analysis established an independent prognostic value for protein p185(neu). Patients with p185(neu) values of the 80th percentile or greater had a risk of death that was 2.11-fold (95% confidence interval, 1.10-4.05) that of patients with values of less than 350 U/mg (P =.03), and increases in the neu oncogene of 100 U/mg increased the probability of death by 17% (P =.02; 95% confidence interval, 1.04-1.31). CONCLUSION: This study shows that the p185(neu) expression is an objective and comparable variable for the assessment of phenotypic aggressivity in non-small cell lung cancer, and in the future, it could be included in daily clinical practice.

Adult↗
PubMed1993

[Interobserver agreement in reading tuberculin tests].

BACKGROUND: The aim of the study was to evaluate the variability between four observers in the reading of the tuberculin test (TT). METHODS: The study was carried out in the Centro de Salud Mendiguchía Carriche (Madrid) 72 subjects. By direct inspection, four observers read tuberculin determination (skin induration) independently in each subject. To assess variability, the kappa index (K) was calculated. RESULTS: On considering the variable as a dichotomous one, with a cut-off point of 5 mm was 0.88; and of 10 mm, 0.78. Upon considering the index as qualitative in four categories the kappa index in 0 mm was 0.89; in 1-4 mm, 0.24; in 5-9 mm, 0.40 and greater than 9 mm, 0.79. In eight of the subjects studied, the variability observed in reading the test had conditioned further different clinico-epidemiologic attitudes. CONCLUSIONS: The degree of concordance when reading TT is significantly lower at the 1-4 mm and 5-9 mm intervals.

Adolescent↗
PubMed1985

Comparison of spontaneous growth hormone secretion during daytime and sleep in children with short stature.

The authors compared diurnal growth hormone (GH) secretion with GH secretion during sleep in 24 children with delayed growth. In group I (children with normal response to provocative tests), the level of daytime secretion was lower than that of nocturnal secretion. In 3 of 9 cases, daytime secretion was abnormal, whereas nocturnal secretion was normal. In 2 cases, both diurnal and nocturnal secretion were abnormal, but response to provocative stimuli was normal. In group II (children with a false partial GH deficiency, i.e. with inadequate response to provocative tests, GH peak less than 11 ng/ml and normal nocturnal secretion), the results were comparable with those of group I, with extremely low diurnal secretion in 6 of 9 cases. In group III (children presenting true partial GH deficiency, i.e. GH less than 11 ng/ml in response to provocative tests together with abnormal nocturnal secretion), both diurnal and nocturnal GH secretion were insufficient, with nonexistent diurnal secretion in 5 of 6 cases. Diurnal secretion does not seem to be a reliable indicator of 24-hour spontaneous secretion.

Adolescent↗
PubMed1985

[Somatotropin secretion during sleep in 60 cases of growth retardation in children].

A study of nocturnal somatotropic secretion with sleep polygraphic recording was performed in 60 children, aged 1 to 18 years and presenting with growth retardation greater than or equal to -2SD. GH secretion was analysed according to the peak value, the number of peaks greater than 5 ng/ml and the integrated concentration (surface under the curve divided by the duration of the test). The children were studied in four groups according to the responses to pharmacologic stimulation tests: a normal group (n = 7), a group with complete somatotropic deficiency (n = 4), a group with partial somatotropic deficiency (n = 39) and a group with dissociated responses (n = 12). Results are concordant between sleep secretion and pharmacologic tests in the first two groups. On the contrary, in the two last, the study of the sleep secretion allows to differentiate children with hyposecretion ("true partial deficiencies") from children with normal secretion ("false partial deficiencies") or abnormal responders). In other respects, correlations between LH maximum peak and stages of sleep are analysed. The maximum peak was observed in only 33.9% of cases during stage IV, 21.5% of cases during stages I, II, III, in 19.6% of cases during wakefulness and in 25% of cases during paradoxical stage. The maximum peak was observed in only 48% of cases during the first cycle of sleep and in 52% of cases during the other cycles. These results show that the correlation between maximum peak, stage IV and first cycle of sleep is not absolute.

Adolescent↗
PubMed1984

[Results of treatment with growth hormone. Apropos of 31 cases of pituitary insufficiency].

The results of treatment with human growth hormone in 31 children with hypopituitarism are reported. 19 boys and 12 girls were treated for several years, six years in three instances. Pituitary insufficiency was idiopathic in 23 cases (isolated in 11 and associated with other deficiencies in 12) and secondary in 8 cases. The mean statural gain during the first year of treatment was 6.3 +/- 2.2 cm with a mean dosage of 9.3 +/- 4 mg/kg/year. The parameters which have the most bearing on statural gain during the first year are: dosage (p less than 0.001) which must be at least equal to 8 mg/kg/year, bone age and chronologic age. In subsequent years statural gain is less significant and seems to be dependent upon the same parameters.

Adolescent↗
PubMedDate not supplied

Effects of pork vs veal consumption on serum lipids in healthy subjects.

AIMS: To analyse the influence of lean pork (P) and veal (V) consumption on the lipid profile of healthy subjects within the framework of a healthy diet comprising low levels of total fat (TF), saturated fatty acids (SFA) and cholesterol. DESIGN: Double-crossover, randomized and controlled trial SUBJECTS: 44 healthy individuals (22 male and 22 female), recruited voluntarily from the University Complutense of Madrid. The weight and lipid profiles of these volunteers were normal and their dietary patterns were typical for people in our area. INTERVENTIONS: The study comprised 4 phases: stabilisation phase (5 weeks), the participants followed their normal diet; second phase (6 weeks), half of the subjects, were randomised to lean pork or veal consumption, 150 g per day, for their main meal of the day; washout period (5 weeks) and final phase, which was the second phase of intervention (6 weeks). During the intervention stages, only the main meal of the day was taken in the Hospital. The rest of the subjects' diets consisted of different fortnightly menus designed in accordance with the recommendations of the Spanish Society of Arteriosclerosis (SEA). RESULTS: After both stages of intervention had been completed, there was a mean reduction of 5.5% in low-density lipoprotein cholesterol. However, after each intervention there were no significant differences between those who had consumed P, 2.62 (0.55) mmol/L and those who had consumed V, 2.71 (0.47) mmol/L. No differences were observed in any of the other parameters between those who had consumed P and those who had consumed V. CONCLUSIONS: Lean pork and veal produces similar effects on the lipid profiles of healthy subjects. Its consumption, as part of the saturated fat and cholesterol-controlled diet, could therefore be included in food guidelines, both for normal and therapeutic diets.

Adult↗