Normal anagen effluvium: a sign of pemphigus vulgaris.
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Adult↗
Biomedical subjects
M T Semino
Publications and source records attributed to M T Semino.
Quantitating hair loss in women: a critical approach.
BACKGROUND: Assessing how many hairs are actually shed by patients complaining of hair loss is a difficult task. Many methods have been proposed, but all need standardization. METHODS: We examined 234 women complaining of hair loss. Alopecia areata and scarring alopecias were excluded. Eighty-nine of the patients had an apparently normal density of hair. Seventy-four were classified as Ludwig stage I, 37 as Ludwig II and 15 as Ludwig III. In 19 patients, classification had not been recorded. They were tested with the pull test (PT), daily count (DC) and wash test (WT). Telogen percentage was obtained by a trichogram in 43 patients. RESULTS: Dispersion of the data was very high. The medians of the PT, DC and WT were 0.6, 60.5 and 122 hairs, respectively. The telogen median of percentage was 16. In patients with normally dense hair, the PT, DC and WT means were significantly higher than in those with Ludwig stages I-III. Telogen means did not differ. WT values correlated significantly with those of the DC and PT, and DC values did so with those of the PT. By contrast, telogen percentage did not correlate with WT, DC and PT values. WT values and telogen percentage increased in autumn, the latter preceding the WT by 1 month. CONCLUSIONS: The methods adopted and the problem of 'normality' are critically analyzed. Subjects complaining of hair loss proved to shed a higher number of hairs than those with various degrees of baldness. The PT is a poorly sensitive method, while telogen percentage is not correlated with the severity of hair loss. As the DC is a cumbersome procedure, the WT is probably the best method to adopt. Standardization of methods and assessment of normality in prepubertal children are imperative.
Alopecia↗
Solitary eccrine syringofibroadenoma (or eccrine syringofibroadenomatous hyperplasia?) and diabetic polyneuropathy.
A 70-year-old diabetic woman with sensory polyneuropathy presented with osteonecrosis of the toes and a plaque-like lesion on the dorsum of the ipsilateral foot. Histological diagnosis of eccrine syringofibroadenoma (ES) was made. A review of the literature reveals several cases of solitary ES of the foot in diabetic patients with peripheral neuropathy. This variant of ES seems to be an eccrine sweat duct hyperplasia during the restoration of skin structures damaged by traumas in a situation of peripheral neuropathy. Diabetes and polyneuropathy should be searched for in patients with ES, particularly in acral locations.
Adenoma, Sweat Gland↗
Unilateral multiple plaque-like syringomas.
We describe a unique presentation of multiple unilateral syringomas characterized by indurated plaques. Histologically, in addition to typical eccrine duct proliferation, desmoplasia exceeding by far that usually observed in syringoma, accounted for the hard consistency of the plaques. This unusual presentation should be added to the numerous clinical variants of syringoma.
Adult↗
[Desmoplastic and neurotropic subungueal melanoma].
INTRODUCTION: Desmoplastic and neurotropic melanoma is rare and involvement of the subungual skin is an exceptional finding. OBSERVATION: We report the second case of desmoplastic and neurotropic subungual melanoma in the literature occurring in a 71-year-old woman. DISCUSSION: In our patient, the histological diagnosis of desmoplastic melanoma was particularly difficult because of the exceptional involvement of the subungual skin. Microscopic neurotropism and immunohistochemical studies were the clues in diagnosing desmoplastic melanoma.
Aged↗