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Biomedical subjects

M Taguchi

Publications and source records attributed to M Taguchi.

At least 181 records · Page 10Linked to original sources
PubMed1983

[Aerosol administration of dibekacin--the sputum concentration].

Serum concentrations of dibekacin (DKB), sisomicin (SISO) and gentamicin (GM) were measured in 3 rabbits after intratracheal administration through the transtracheal teflon tube. The peak serum levels (average) were 106 micrograms/ml (administrated 100 mg DKB for injection), 148 micrograms/ml (administrated 100 mg DKB solution), 166 micrograms/ml (administrated 100 mg SISO solution) and 80 micrograms/ml (administrated 80 mg GM solution). Serum concentrations and urine excretions of DKB were measured in 3 volunteers after aerosol administration using ultrasonic nebulizer. The peak serum levels (average) were 4.6 micrograms/ml (administrated 100 mg DKB for injection) and 3.1 micrograms/ml (administrated 100 mg DKB solution). The urine excretions (average) were 3.7 mg and 4.3 mg respectively during 6 hours. Before and after administration of DKB aerosol the spirogram and flow-volume curve were examined in the volunteers. But the examinations showed no changes. Sputum concentrations were measured in 1 patient with chronic bronchobronchiolitis after administration of DKB aerosols using the ultrasonic nebulizer. The highest sputum concentration was acquired immediately after nebulization and the sputum levels decreased gradually while time passed. Six patients with the lower respiratory tract infections were treated with DKB aerosol therapy and the utility rate was 80%.

Adult↗
PubMed1982

[Fundamental and clinical studies of cefotiam in the field of oral surgery].

Cefotiam (CTM) is a new synthetic cephem antibiotic developed in Japan. The results of the fundamental and clinical studies are as follows. 1. CTM showed antibacterial activity, in terms of MIC, as strong as those of cephalothin (CET) and cefazolin (CEZ) for Gram-positive cocci, and several times superior to for Gram-negative bacilli. 2. CTM serum levels approximately reached the peaks on completion of 60 minutes intravenous drip infusion of 1 g of this preparation dissolved in 5% glucose solution of 250 ml; the mean value was 65.00 micrograms/ml. Then the levels dropped rather quickly up to 180 minutes after the start of drip infusion. After that, the levels dropped gradually up to 360 minutes. 3. As for the passage of CTM in the oral tissues, satisfactory passage was observed in both maxillomandibular marrow and gingiva, which adequately exceeded MICs of the clinically isolated strains of oral infections. 4. This preparation was administered 1 g of 2 g daily by intravenous drip infusion in 18 cases of moderate or more serious infections in the field of oral surgery; the clinical efficacy rate obtained was 94.4%. 5. No manifestations of side effect were observed clinically. As for laboratory findings, 1 case of large increases in GOT and GTP (a hepatitis B antigen positive patient) and 2 cases of slight increase in GTP were observed. On the basis of these results of the fundamental and clinical studies, it was concluded that CTM is an excellent antibiotic for the treatment of oral infections.

Adolescent↗
PubMed1982

[Experimental and clinical studies of cefmetazole in the field of oral surgery].

Experimental and clinical studies were carried out on cefmetazole (CMZ), a synthetic antibiotic of cephamycin group, and the following results were obtained. 1) The minimal inhibitory concentrations (MICs) of CMZ against Gram positive cocci (30 strains) isolated from the patients with oral infections showed slightly inferior to those of ABPC, CEZ, while MICs against Gram negative bacilli (166 strains) of CMZ exhibited stronger activity than ABPC, CEZ. 2) The mean serum concentration of CMZ at 60 minutes after drip infusion showed 65.6 micrograms/ml. The concentration of CMZ in oral tissues varied in 4--60% of serum level at 60 minutes after drip infusion. The concentration in pus showed 15.2 micrograms/g at 60 minutes after drip infusion. 3) CMZ was administered by the drip infusion to 22 patients with various infections in the oral surgical field. The efficacy rate was 90.9%. 4) No side effect was observed.

Adult↗
PubMed1982

[Serum ferritin level for estimating the effect of the radiotherapy].

Serum ferritin level was evaluated as a marker for estimating the effect of the radiotherapy. The ferritin level was determined by a radioimmunoassay (SPAC ferritin kit) in sera obtained serially from 37 patients with various malignant neoplasma before and after radiotherapy. The changes in the ferritin level were investigated in comparison with various clinical findings. The decision for significant changes in the ferritin level was made by the sensitivity which is a difference value necessary to discriminate 2 values at confidence level of 95%. Out of 11 cases with clinical evidence of distant metastasis, the ferritin level was decreased in only one case (9%) and increased or unchanged in the rest. On the other hand, out of 26 cases without evidence of metastasis it was decreased in 9 cases (35%) and unchanged in 12 cases (46%). The ferritin level was either decreased (64%) or unchanged (36%) in all the 11 cases with operation prior to radiotherapy, while out of 26 cases without operation (inoperable) it was decreased in only 3 cases (12%). In all 5 cases with radiosensitive tumors as judged by tumor size the ferritin level was either decreased (40%) or unchanged (60%). Out of 28 cases with radioresistant tumors it was decreased in only 4 cases (14%). All of these results indicated that serial measurements of the ferritin level is usefull for estimating the therapeutic effectiveness in radiotherapy.

Evaluation Studies as Topic↗