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M Talmor

Publications and source records attributed to M Talmor.

26 records · Page 2Linked to original sources
PubMed1993

Acquired ichthyosis in concomitant HIV-1 and HTLV-II infection: a new association with intravenous drug abuse.

BACKGROUND: Papulosquamous eruptions are common in HIV-1-infected patients. Acquired ichthyosis may occur after profound T-cell depletion. Intravenous drug users infected with HIV-1 can be coinfected with human lymphotropic virus II (HTLV-II). OBJECTIVE: We examined the relation between acquired ichthyosis and concomitant infection with HIV-1 and HTLV-II in intravenous drug users. METHODS: We examined 184 male and female HIV-1-positive intravenous drug users for acquired ichthyosis. Enzyme-linked immunosorbent assay was used to screen these patients for antibody to HTLV-I/II. Western blot, viral isolation, and the polymerase chain reaction were used to confirm that serologic responses were from HTLV-II and not HTLV-I. RESULTS: Acquired ichthyosis occurred in 6.3% of white, 16.4% of Hispanic, and 21.7% of black patients. It occurred only after profound helper T-cell depletion, in association with increasing age, and with concomitant infection with HTLV-II (22.2% vs. 6.8% in HIV-1 singly infected patients [p < 0.038]). CONCLUSION: Acquired ichthyosis may be a marker of concomitant infection with HIV-1 and HTLV-II in intravenous drug users and occurs after profound helper T-cell depletion.

Acquired Immunodeficiency Syndrome↗
PubMed1991

Acquired trichomegaly of the eyelashes: a cutaneous marker of acquired immunodeficiency syndrome.

Acquired trichomegaly of the eyelashes was found in seven patients infected with human immunodeficiency virus type 1. These patients had advanced infection with severe T-helper cell depletion, high levels of p24 antigenemia, and inability to tolerate zidovudine therapy. Control of infection with other antiretroviral agents caused the trichomegaly to regress. Acquired trichomegaly may be a useful clinical marker for assessment of severity of infection.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Chronic T cell lymphocytosis with large granular lymphocytes of helper (OKT4) phenotype.

A 54-year-old asymptomatic male patient was followed for more than 7 y and presented a constant T cell lymphocytosis without skin involvement or bone marrow depression. No clinical or haematological aggravation was noted during this follow-up. Morphologically, the cells were large granular lymphocytes strongly positive for beta-D-glucuronidase, negative for acid phosphatase and with features of T cells on transmission and scanning electron microscopy. The immunological studies of the lymphocytes showed the following parameters: E rosettes+, mouse rosettes-, SmIg-, OKT3+, OKT4+, OKT8-, OKT6-, Ia-, TdT-, NK-, HTLV-, decreased PHA and PWM stimulation, no interleukin 2 production and failure to enhance Ig synthesis in a PWM driven system. The karyotype was normal. This case of chronic T cell lymphocytosis with large granular lymphocytes helper profile and defect of helper function, not reported in the literature, may correspond to a distinct entity in the heterogeneous group of chronic T cell disorders.

Antibodies, Monoclonal↗
PubMed1984

Rosetting index (E rosettes/mouse rosettes): a simple diagnostic and prognostic value in CLL.

The rosetting index (E rosettes/mouse rosettes) was evaluated in 34 controls, 4 chronic benign lymphocytosis and 28 CLL patients, grouped according to the Rai classification: 6 asymptomatic stage 0 patients (lymphocytosis less than 10,000/mm3) with a rosetting index of 0.35 +/- 0.2; 11 asymptomatic stage 1-2 patients (lymphocytosis 10,000-40,000/mm3) with a rosetting index of 0.19 +/- 0.11; 9 symptomatic stage 3-4 patients (lymphocytosis greater than 40,000/mm3) with a rosetting index of 0.09 +/- 0.09 and 2 T-CLL patients post splenectomy and 4 chronic benign lymphocytosis patients with a rosetting index of 25 +/- 15. The average rosetting index for the controls was 10.0 (range 3.5-54). Student's t test was p less than 0.0001 for groups 1, 2 and 3 and p less than 0.02 for group 4. These results show that the rosetting index is helpful for the characterization of B-CLL in all stages, the rosetting index decreases with the proliferative activity of the disease and could be used as a prognostic factor, and the rosetting index is significantly increased in T-CLL and chronic benign T lymphocytosis thus being useful in differentiating these conditions from the early stage of CLL, when the SmIg is not conclusive of a monoclonal proliferation.

Animals↗
PubMed1983

IgM lambda globular cytoplasmic inclusions in chronic lymphocytic leukaemia resembling immunocytoma.

In a 64-year-old female with chronic lymphocytic leukaemia, nearly 50% of the lymphocytes presented one or several globular intracytoplasmic inclusions resembling Russell bodies which were characterized by immunofluorescence as IgM lambda. On electron microscopy, the inclusions looked like cisternae of the rough endoplasmic reticulum. Surface membrane Ig was not detected and the serum IgM was low. The histology of a lymph node showed a lymphocytic proliferation with evidence of Ig synthesis, compatible with immunocytoma. The aggressive course of the disease necessitated polychemotherapy. This case represents an unusual ill-defined lymphoproliferative disorder, lying between the B-CLL and a non-secretory macroglobulinaemia.

Cytoplasm↗
PubMedDate not supplied

Laser tissue welding: a biotechnological advance for the future.

Laser tissue welding as well as other alternative methods of closure will play a more important role in surgical specialties as laparoscopic, endoscopic, and microsurgical techniques continue to develop. Laser tissue welding uses laser energy to anastomose tissues and is ideally suited for applications in which suturing and stapling is difficult. Recent advances have led to a better understanding of the mechanisms of tissue welding. Additionally, technical achievements including the introduction of protein solders and temperature-controlled feedback systems have led to the acceptance of laser tissue welding in clinical medicine. In this article, we describe the history and development of laser tissue welding and review the current and potential applications of this technology.

Animals↗