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M Tanigawa

Publications and source records attributed to M Tanigawa.

117 records · Page 7Linked to original sources
PubMed1984

[Sensitization of a cell line, CEM by indomethacin. A study of the underlying mechanism].

A cell line, CEM, was derived from a patient with acute lymphocytic leukemia. We investigated the underlying mechanisms for a phenomenon in which CEM became more sensitive to attack by antiserum and complement when cultured with indomethacin, a prostaglandin (PG) synthesis inhibitor. Other PG synthesis inhibitors also evoked similar sensitization. When PGE2 was further added to the culture, the sensitization was suppressed. Both findings indicate that a decrease of PG may be one of the mechanisms. Inhibition of metabolism, and decrease of CEM surface antigen shed from the cell into the supernatant also seem responsible for the sensitization.

Antigens, Surface↗
PubMedDate not supplied

Disseminated mycobacterial infection in a hemophilia B patient with acquired immunodeficiency syndrome.

Disseminated mycobacterial infection was found at autopsy in a male patient with hemophilia B and acquired immunodeficiency syndrome (AIDS). In May 1986, 23 months before death, the patient had encephalitis for one month and in July he developed a fever, malaise and generalized lymphoadenopathy. Human immunosuppressive virus (HIV) was positive and the CD 4/8 ratio of lymphocyte surface markers was 0.1, but mycobacterium was not detected. In September 1986, he had severe dyspnea due to interstitial pneumonia and he was treated with high-dose methylprednisolone. He died after a 23-month course of fever, severe weight loss and terminal progressive deterioration, although he was treated with antibiotics, antifungal agents, gamma-globulin, steroid and a Azidothymidine.

Acquired Immunodeficiency Syndrome↗