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M Tanimoto Weki

Publications and source records attributed to M Tanimoto Weki.

4 recordsLinked to original sources
PubMed1978

Production of cecal lesions in newborn guinea pigs with axenically cultivated Entamoeba histolytica.

The production of cecal lesions with axenically cultivated Entamoeba histolytica in an experimental animal is reported for the first time. Forty-three newborn guinea pigs (one to five days old) were inoculated via laparatomy with 2.5 x 10(5) to 2 x 10(6) strain HM-1-IMSS amebae. Of 23 animals surviving to the 7th postinoculation day all showed cecal lesions at necropsy regardless of the age of the animal when used or the number of amebae received. Ten animals had lesions visible to the unaided eye and 13 had only microscopic lesions. No lesions were noted in other organs of the abdominal or thoracic regiosn. The use of axenically cultivated ameabae in newborn guinea pigs should prove a useful experimental model for the study of amebiasis.

Animals↗
PubMedDate not supplied

[Amebiasis. Has its clinical expression changed?].

In Mexico, like in other countries, there is an special interest for amebiasis because it represents a Public health problem; there are about 5 million people that in some time of their lives had tissue invasion by this parasite. 1-2% of mexicanas have intestinal amebiasis and probably there are 850,000 to 1,700,000 carriers of entamoeba cysts. 6% of the general population have circulating antiameba antibodies. In 1988 we studied the amebic hepatic abscess seen in the hospitals of the Instituto Mexicano del Seguro Social in the Valley of Mexico. During that year there were 396 patients with such illness (0.19% of hospital admissions) with a 1.01% mortality. Comparing this data with reports of 1969 there was a reduction in the number of patients and deaths. Also amebiasis has decreased in autopsy studies. However, we have not found recent variations in the clinical behavior of amebiasis. Advances in diagnostic methods and more liberal use of metronidazole have reduced the number of severely ill patients.

Amebiasis↗