Biomedical subjects

M Tanter

Publications and source records attributed to M Tanter.

9 recordsLinked to original sources

PubMed2003

High power transcranial beam steering for ultrasonic brain therapy.

A sparse phased array is specially designed for non-invasive ultrasound transskull brain therapy. The array is made of 200 single elements corresponding to a new generation of high power transducers developed in collaboration with Imasonic (Besançon, France). Each element has a surface of 0.5 cm2 and works at 0.9 MHz central frequency with a maximum 20 W cm(-2) intensity on the transducer surface. In order to optimize the steering capabilities of the array, several transducer distributions on a spherical surface are simulated: hexagonal, annular and quasi-random distributions. Using a quasi-random distribution significantly reduces the grating lobes. Furthermore, the simulations show the capability of the quasi-random array to electronically move the focal spot in the vicinity of the geometrical focus (up to +/- 15 mm). Based on the simulation study, the array is constructed and tested. The skull aberrations are corrected by using a time reversal mirror with amplitude correction achieved thanks to an implantable hydrophone, and a sharp focus is obtained through a human skull. Several lesions are induced in fresh liver and brain samples through human skulls, demonstrating the accuracy and the steering capabilities of the system.

Brain↗

PubMed2003

Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans.

Developing minimally invasive brain surgery by high-intensity focused ultrasound beams is of great interest in cancer therapy. However, the skull induces strong aberrations both in phase and amplitude, resulting in a severe degradation of the beam shape. Thus, an efficient brain tumor therapy would require an adaptive focusing, taking into account the effects of the skull. In this paper, we will show that the acoustic properties of the skull can be deduced from high resolution CT scans and used to achieve a noninvasive adaptive focusing. Simulations have been performed with a full 3-D finite differences code, taking into account all the heterogeneities inside the skull. The set of signals to be emitted in order to focus through the skull can thus be computed. The complete adaptive focusing procedure based on prior CT scans has been experimentally validated. This could have promising applications in brain tumor hyperthermia but also in transcranial ultrasonic imaging.

Acoustics↗

PubMed2001

Breaking of time reversal invariance in nonlinear acoustics.

Time-reversal invariance of nonlinear acoustic wave propagation is experimentally investigated. Reversibility is studied for propagation shorter or longer than shock formation distance. In the first case, time-reversal invariance holds and a sinusoid distorted by nonlinearities during forward propagation progressively recovers its initial shape after the time-reversal operation. In the second case, reversibility is broken locally at the shock front as a time-reversal operation transforms a stable compression shock into an unstable expansion shock. Achieving experimentally the time-reversal process with a time-reversal mirror made of reversible piezoelectric transducers for very broadband signals, would require transducers with huge bandwidths. To date, such transducers remain unavailable. In order to overcome this technical limitation, we restricted ourselves in this study to one-dimensional (1D) propagation, for which an experimental ersatz of a time-reversal mirror can be used. Indeed, in a 1D case, the time-reversal operation applied on a plane wave can be mimicked for an antisymmetric wave form by a reflection of the plane wave onto a pressure-release interface.

Journal Article↗

PubMed2001

Scattering of sound by a vorticity filament: an experimental and numerical investigation.

A vorticity filament is investigated experimentally using the transmission of an ultrasonic wave through the flow. The analysis of the wave-front distortion provides noninvasive measurements of the vortex circulation and size. The latter is estimated by analytical calculations of the scattering of a plane wave by a vorticity filament. The case of a cylindrical wave incident on a vortex leads to similar experimental results which are successfully compared to a parabolic equation simulation. Finally, a finite-difference code based on linear acoustics is presented, in order to investigate the structure of the scattered wave numerically.

Journal Article↗

PubMed2001

Optimal focusing by spatio-temporal inverse filter. I. Basic principles.

A focusing technique based on the inversion of the propagation operator relating an array of transducers to a set of control points inside a medium was proposed in previous work [Tanter et al., J. Acoust. Soc. Am. 108, 223-234 (2000)] and is extended here to the time domain. As the inversion of the propagation operator is achieved both in space and time, this technique allows calculation of the set of temporal signals to be emitted by each element of the array in order to optimally focus on a chosen control point. This broadband inversion process takes advantage of the singular-value decomposition of the propagation operator in the Fourier domain. The physical meaning of this decomposition is explained in a homogeneous medium. In particular, a definition of the number of degrees of freedom necessary to define the acoustic field generated by an array of limited aperture in a focal plane of limited extent is given. This number corresponds to the number of independent signals that can be created in the focal area both in space and time. In this paper, this broadband inverse-focusing technique is compared in homogeneous media with the classical focusing achieved by simple geometrical considerations but also with time-reversal focusing. It is shown that, even in a simple medium, slight differences appear between these three focusing strategies. In the companion paper [Aubry et al., J. Acoust. Soc. Am. 110, 48-58 (2001)] the three focusing techniques are compared in heterogeneous, absorbing, or complex media where classical focusing is strongly degraded. The strong improvement achieved by the spatio-temporal inverse-filter technique emphasizes the great potential of multiple-channel systems having the ability to apply completely different signal waveforms on each transducer of the array. The application of this focusing technique could be of great interest in various ultrasonic fields such as medical imaging, nondestructive testing, and underwater acoustics.

Echoencephalography↗

PubMed2001

Optimal focusing by spatio-temporal inverse filter. II. Experiments. Application to focusing through absorbing and reverberating media.

To focus ultrasonic waves in an unknown heterogeneous medium using a phased array, one has to calculate the optimal set of signals to be applied on the transducers of the array. (In most applications of ultrasound, medical imaging, medical therapy, nondestructive testing, the first step consists of focusing a broadband ultrasound beam deeply inside the medium to be investigated.) Focusing in a homogeneous medium simply requires to compensate for the varying focus-array elements geometrical distances. Nevertheless, heterogeneities in the medium, in terms of speed of sound, density, or absorption, may strongly degrade the focusing. Different techniques have been developed in order to correct such aberrations induced by heterogeneous media (time reversal, speckle brightness, for example). In the companion to this paper, a new broadband focusing technique was investigated: the spatio-temporal inverse filter. Experimental results obtained in various media, such as reverberating and absorbing media, are presented here. In particular, intraplate echoes suppression and high-quality focusing through a human skull, as well as hyper-resolution in a reverberating medium, will be shown. It is important to notice that all these experiments were performed with fully programmable multichannel electronics whose use is required to fully exploit the spatio-temporal technique.

Echoencephalography↗

PubMed2000

Time reversal and the inverse filter.

To focus ultrasonic waves in an unknown inhomogeneous medium using a phased array, one has to calculate the optimal set of signals to be applied on the transducers of the array. In the case of time-reversal mirrors, one assumes that a source is available at the focus, providing the Green's function of this point. In this paper, the robustness of this time-reversal method is investigated when loss of information breaks the time-reversal invariance. It arises in dissipative media or when the field radiated by the source is not entirely measured by the limited aperture of a time-reversal mirror. However, in both cases, linearity and reciprocity relations ensure time reversal to achieve a spatiotemporal matched filtering. Nevertheless, though it provides robustness to this method, no constraints are imposed on the field out of the focus and sidelobes may appear. Another approach consists of measuring the Green's functions associated to the focus but also to neighboring points. Thus, the whole information characterizing the medium is known and the inverse source problem can be solved. A matrix formalism of the propagation operator is introduced to compare the time-reversal and inverse filter techniques. Moreover, experiments investigated in various media are presented to illustrate this comparison.

Humans↗

PubMed1999

Time-resolved pulsed elastography with ultrafast ultrasonic imaging.

In this paper, a new elastographic method is proposed. Using this method, the propagation of a low-frequency transient shear wave can be imaged by means of an ultrafast imaging system (up to 10,000 frames/s) that we have developed. Ultrafast ultrasonic imaging is obtained with a linear array of transducers (3.5 MHz) connected to electronics that have 64 channels sampled at 30 MHz and 128 Kbytes for storing the backscattered signals. Displacements are measured using cross-correlation of the ultrasonic signals. Movies of the low central frequency (200 Hz) shear wave propagation through homogeneous and heterogeneous phantoms have been obtained with 1,000 and 2,000 frames per second.

Elasticity↗

PubMed1998

Focusing and steering through absorbing and aberrating layers: application to ultrasonic propagation through the skull.

The time-reversal process is applied to focus pulsed ultrasonic waves through the human skull bone. The aim here is to treat brain tumors, which are difficult to reach with classical surgery means. Such a surgical application requires precise control of the size and location of the therapeutic focal beam. The severe ultrasonic attenuation in the skull reduces the efficiency of the time reversal process. Nevertheless, an improvement of the time reversal process in absorbing media has been investigated and applied to the focusing through the skull [J.-L. Thomas and M. Fink, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 43, 1122-1129 (1996)]. Here an extension of this technique is presented in order to focus on a set of points surrounding an initial artificial source implanted in the tissue volume to treat. From the knowledge of the Green's function matched to this initial source location a new Green's function matched to various points of interest is deduced in order to treat the whole volume. In a homogeneous medium, conventional steering consists of tilting the wave front focused on the acoustical source. In a heterogeneous medium, this process is only valid for small angles or when aberrations are located in a layer close to the array. It is shown here how to extend this method to aberrating and absorbing layers, like the skull bone, located at any distance from the array of transducers.

Brain Neoplasms↗