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Biomedical subjects

M Targett

Publications and source records attributed to M Targett.

4 recordsLinked to original sources

MRI findings in a dog with discospondylitis caused by Bordetella species.

A case of discospondylitis in a dog secondary to Bordetella species, diagnosed early with the assistance of magnetic resonance imaging (MRI), is reported. The history and clinical signs were suggestive of possible discospondylitis. MRI identified changes and allowed a presumptive diagnosis of discospondylitis, which was subsequently confirmed by bacterial culture of biopsy material. Discospondylitis associated with Bordetella species infection has not, to the authors' knowledge, been previously reported in the dog.

Animals↗

Determinism, indeterminism, and explanatory bias.

Actions are a subclass of human behaviours which are distinguished, on a modest view, by certain antecedent mental and neural processes and events, including desires and beliefs. Libertarian philosophies have taken a less modest view, according to which some actions come under the influence of individual persons in a way distinct from being the necessary effect of a sequence of psychoneural events. Determinism claims necessary connections between sequences of events and conditions, including those sequences that involve desires and beliefs and subsequent actions. Even if a certain interpretation of modern physics shows determinism to be false, the sense of personal influence over action which libertarians have remains obscure. It is not enlightened by the physicist's idea of inexplicable fluctuations between courses of events with greater or lesser probabilities. If libertarianism remains obscure, so do the grounds for an approach to explaining behaviour which might be called "explanatory individualism". According to the latter stance, the local outcomes of actions and larger social tendencies are only properly explained in terms of the choices of individuals, rather than, for example, their neural or environmental antecedents. Again, bare indeterminism will not help to supply the required grounds. A more justifiable stance is "explanatory pluralism", a doctrine which denies the intrinsic priority of individualistic modes of explanation over those which focus on psychoneural, environmental, social or genetic conditions. It is stressed that on a sensible pluralism, any determinism which correctly describes the history of actions would be no more "genetic", than indeterminism could be "individualistic".

Behavior↗

Accuracy of survey radiographic diagnosis of intervertebral disc protrusion in dogs.

To assess the diagnostic accuracy of survey radiography for canine thoracolumbar intervertebral disc protrusion, survey radiographs (lateral and ventrodorsal) of 64 dogs with surgically-confirmed thoracolumbar intervertebral disc protrusion, 51 dogs with negative myelograms and 29 dogs with various spinal conditions other than disc protrusion were reviewed by three independent observers who were unaware of any clinical information. There were marked differences in observer performance for diagnosis of intervertebral disc protrusion, although there were no significant differences in intraobserver diagnostic accuracy for small vs. large dogs. Accuracy of observers for determining sites of intervertebral disc protrusion using survey radiography was in the range 51-61%. All observers had low accuracy for identification of second sites of intervertebral disc protrusion. The most useful radiographic sign, narrowed intervertebral space, had only moderate sensitivity (range 64-69%) and moderate predictive value (range 63-71%) for intervertebral disc protrusion. Vacuum phenomenon was an infrequent but accurate sign of intervertebral disc protrusion. Recognition of multiple radiographic signs of intervertebral disc protrusion at one site was associated with increased accuracy of diagnosis. No observer was accurate enough to justify attempting targeted surgical treatment of intervertebral disc protrusion without myelography.

Animals↗