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Biomedical subjects

M Tazartes

Publications and source records attributed to M Tazartes.

5 recordsLinked to original sources
PubMed2002

[Thyroid orbital pathologies in ophthalmological settings].

OBJECTIVE: To illustrate the originality and diversity of an ophthalmologic pathology associated with a thyroid disease (OATD), we report 42 cases of patients hospitalised or having consulted an ophthalmologic department for this disease over a period of 4 years. METHOD: Each patient was assessed by an endocrinologist and an ophthalmologist. Data included the OATD severity score, date of occurrence compared with the thyroid disease and determination of thyroid function and immune abnormalities. RESULTS: Patients were aged a mean of 48.9 + 15.3 years; 65% were women and 39% smokers. OATD preceded the thyroid disease in 38% of cases, was concomitant in 40% and successive in 21%. Thirty-six percent of cases were mild, 45% moderate and 19% were severe. One patient out of 5 had exhibited a period of iatrogenic hypothyroidia. The majority (81%) presented with Basedow's disease; 14% Hashimoto's disease; 73% anti-TSH receptor antibodies and 56% anti-thyroperoxidase antibodies. Two profiles of patients with OAMT were identified. A first group with severe OATD: Basedow's disease, presence of anti-TSH receptor antibodies and a period of iatrogenic hypothyroidia in half of the cases. A second group in which the occurrence of OATD preceded diagnosis of a thyroid disease: generally non-severe forms with varying thyroid status, strongly related to the moment at which the patient consulted, compared with the progression of the ophthalmologic and thyroid affections. CONCLUSION: When faced with signs evoking OATD, these data emphasize the need for an evaluation of thyroid status and determination of the antibodies implied in Basedow and Hashimoto's disease. After initiation of synthetic anti-thyroid or radioactive iodine therapy, the evolution of the thyroid and ophthalmologic status of hyperthyroid patients must be carefully monitored.

Adult↗
PubMed2001

[Prognostic outcome of leaking filtering blebs reconstruction with rotational conjunctival flaps].

PURPOSE: Late bleb leaks may follow months to years after filtering surgery especially with the use of antimetabolites. Complications related to beb leaks may lead to a decrease in visual acuity through complicated hypotony or ocular infection. Our retrospective study reports the anatomical and functional results of bleb reconstruction involving the resection of the bleb associated with the covering of the trabeculectomy site with a rotational conjunctival flap. MATERIAL: and methods: Twelve eyes of eleven patients with filtering bleb leaks occurring 3 months to 5 years after successful trabeculectomy (58.3% with adjunct of antimetabolites) underwent bleb surgical reconstruction between november 1995 and June 1999 and were followed until March 2000. Surgical bleb reconstruction was indicated because of persistent or a recurring bleb leak despite conservative medical treatment and blood bleb injections in seven cases. Complications associated with bleb leaks were chronical hypotony (9 cases), athalamy (1 case), hypotony maculopathy (1 case), and endophtalmitis with athalamy (1 case). Three patients had normal IOP but a bleb leak responsible for epiphora. All eyes were treated surgically through bleb excision and conjunctival closure was performed by rotational conjunctival flap. RESULTS: Mean (+/- SD) preoperative IOP was 5.1+/-3.5mmHg (range: 2 to 14mmHg). Mean (+/- SD) postoperative IOP evaluated before any other operation for uncontrolled IOP was 12.7+/-3.1mmHg (range: 6 to 15mmHg). Mean follow-up was 26.7+/-16.9 months (range: 9 to 64 months). All the complications related to the bleb leak resolved after bleb reconstruction. Surgery definively stopped the leak in 10 cases (83.3%) and allowed IOP control without treatment in 50.0% of the cases. Chronic recurring bleb leaks without hypotony occurred in two eyes and required surgery with conjunctival graft which led to a refractory increase in IOP responsible for loss of vision in one case. CONCLUSION: Bleb resection associated with the covering of the trabeculectomy site with a rotational conjunctival flap is a safe and effective procedure for the treatment of a late bleb leak and its complications. In most of the cases (83.3%), long-term IOP control can be expected without, medical treatment in 50% of the cases. Patients must be aware of the possibility of a recurring Seidel; however, the incidence of this complication remains low.

Adult↗
PubMed1998

Treatment of common ocular allergic disorders; a comparison of lodoxamide and NAAGA.

BACKGROUND/AIMS: Lodoxamide tromethamine and N-acetyl-aspartyl glutamic acid (NAAGA) are mast cell stabilisers, both of which have been shown to be effective in the treatment of allergic conjunctivitis. The aim of this study was to compare the two compounds in patients with common ocular allergic disorders. METHODS: 73 patients participated in a double masked, randomised multicentre study. Diagnoses were chronic allergic conjunctivitis, vernal conjunctivitis, seasonal and atopic conjunctivitis. 36 patients were treated with lodoxamide 0.1% and 37 with NAAGA 4.9%, the drops being instilled four times daily for up to 56 days. RESULTS: The overall opinion of the physicians and the patients was in favour of lodoxamide at day 10 of the study. At this time, 86% of lodoxamide treated and 49% of NAAGA treated patients considered they had improved. The patients' opinion favoured lodoxamide at day 28 and both physicians' and patients' evaluations were in favour of lodoxamide at day 42. Evaluation of signs and symptoms indicated superiority of lodoxamide at days 42 and 56. Both treatments were well tolerated. CONCLUSION: While both lodoxamide and NAAGA treatments are associated with clinical improvements in patients with allergic conjunctivitis, lodoxamide may have an earlier onset of action.

Adolescent↗
PubMed1988

[Juvenile aggressive palpebral fibromatosis. Apropos of a case].

Juvenile Aggressive Fibromatosis (JAF) is histologically characterized by a fibroblastic cellular proliferation. Even though benign, it is locally invasive and very often recurrent but never induces metastasis; the evolutionary argument is the only one which enables us to differentiate JAF from fibrosarcoma. The selected treatment is extensive surgical excision including healthy tissue with histological control. The prognosis is variable depending upon localization and therapeutic possibilities. We report the case of a seven year-old girl presenting an eyelid localization which is seldom reported. The extraorbital and intracranial extension was fatal in spite of the therapy associating surgery, radiotherapy and chemotherapy. The central nervous system proximity poses a difficult problem and speaks for an early mutilating surgery. However, the small number of published cases does not yet allow codification of treatment.

Child↗