[Hemodynamic evaluation of the results of surgical treatment of advanced mitral valve disease].
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Biomedical subjects
Publications and source records attributed to M Tendera.
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Six medically treated patients with kinking of the aorta (3 with concomitant aortic stenosis) were followed up for a mean of 51 months. Four patients died and in one survivor apparent radiologic progression occurred. The authors conclude that kinking of the aorta has a more serious outcome than commonly appreciated.
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In 24 patients with acute inferior myocardial infarction, the presence and duration of ST-segment depression in lead V2 correlated with the presence of left anterior descending coronary artery (LAD) stenosis and depressed left ventricular ejection fraction (LVEF). Early changes in lead V2 (within 4 hours after the onset of pain) were 67% sensitive and only 42% specific, whereas late changes (after onset of inferior Q waves and more than 6 hours after the onset of pain) were 42% sensitive, but 100% specific for the presence of LAD stenosis or decreased LVEF or both. Thus, in patients with inferior infarction, only the late repolarization change is helpful in identifying those with LAD stenosis or decreased LVEF. The absence of lead V2 ST-segment depression on either early or late electrocardiograms does not imply a normal LAD or LVEF.
In a community hospital, we correlated results of thallium 201 myocardial scintigraphy with coronary arteriographic data in 79 patients. Scintigraphy was 92% sensitive and 85% specific in detecting coronary artery disease. There were no false-negative scintigrams in patients with double or triple vessel disease. The most important factors determining sensitivity of the method in detecting individual coronary stenoses were (1) location of the stenosis in the coronary tree, (2) number of vessels involved, and (3) degree of obstruction. Higher prevalence of perfusion defects in areas of 90% to 99% stenosis as compared with 50% to 89% lesions was of borderline statistical significance (86% vs 59%; P = .06). Myocardial perfusion scintigraphy was unable to predict the number of significantly narrowed coronary vessels. Predictive value of a perfusion defect for a significant coronary stenosis was 87% for anterior, 88% for septal, 90% for lateral, 89% for posterior, and 78% for inferior segment. We conclude that segmental analysis of myocardial scintigrams may be of value in a community hospital.
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In 16 patients with hypertrophic cardiomyopathy, an acute response of the left ventricular end-diastolic pressure and volume index to intravenously administered verapamil was assessed. Verapamil decreased the left ventricular end-diastolic pressure from 20 +/- 6 to 17 +/- 5 mm Hg(p less than 0.001) and increased the end-diastolic volume index from 82 +/- 22 to 91 +/- 23 ml/sqm (p less than 0.01). In 13 (81 percent) of 16 patients, an improvement of end-diastolic pressure-volume relationships occurred. In hypertrophic cardiomyopathy, intravenous verapamil exerts a beneficial effect on left ventricular filling conditions, producing an augmentation of filling volume at a lower filling pressure.
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