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Biomedical subjects

M Teokharova

Publications and source records attributed to M Teokharova.

4 recordsLinked to original sources
PubMed1975

[Serologic studies in viral hepatitis].

Comparative studies of sera from 710 patients with viral hepatitis and contacts were made during the 1958-1973 period for hepatitis antigens (Au antigen and the Botevgrad antigen). The percentage of virus hepatitis in patients positive for the Au and the Botevgrad antigens varied in different years. The percentage of those positive for the Au antigen ranged from 50 in 1958 to 8.8 in 1970-1971, while for the Botevgrad antigen--it ranged from 32.6 in 1962-1963 to 6.1 in 1966. In case of contacts, mostly in the 7-14 age group the sera positive for the Au antigen were found in a low percentage (2.09 percent) of cases; as to the Botevgrad antigen, 20 persons were found positive during various epidemics (55 percent). Simultaneous presence of both antigens was found in 4 of the 710 patients with virus hepatitis (0.56 percent), and in 2 of 431 contacts (0.46 percent).

Antigens, Viral↗
PubMedDate not supplied

[Development of cellular immunity in patients with viral hepatitis].

The development of cell-mediated immunity (CMI) to the surface antigen of hepatitis B virus (HBSAg) and Botevgrad antigen (BA) was traced in 50 hepatitis patients. Migration inhibition test (MIT) was performed with purified HBSg and AB. Blood samples from every hepatitis patient were obtained at the beginning of the icteric phase, 10 days later and during convalescence. There was correlation between the two types of viral hepatitis and the type of cellular immune response. The development of CMI is associated with disappearance of HBSAg from the serum of hepatitis patients. CMI to HBSAg develops within 9-12 days after the onset of icterus and to BA during the first two days of icterus. There is a relationship between the persistence of HBSAg and CMI.

Bilirubin↗
PubMedDate not supplied

[DNA, RNA and protein synthesis in hepatitis A virus-infected cells].

Synthesis of DNA, RNA, and protein macromolecules was observed in cells infected with a strain of HA virus which had undergone 11 passages in the same culture. At 24-hour intervals the infected and uninfected cells were pulse-labeled with 1 microCi/cc 3H-thymidine, 3H-uridine, and 14C-valine. In 6-9 days after cell inoculation, inhibition of DNA, RNA, and protein synthesis was observed, being most marked in DNA synthesis. The synthesis of these macromolecules increases on the 10-13th day which coincides with virus antigen accumulation in the cell cytoplasm.

Animals↗