Biomedical subjects
Publications and source records attributed to M Thonnet.
Authors have selected 1928 measurements of thyroglobulin and studied their value in the thyroid pathology. They show that elevated values of thyroglobulin, the only one response in this pathology, can, even if isolated, be the mode of revelation of thyroid illness. They insist, in order to explain this fact, on the presence of a "sixth factor" which depends upon the quality of the thyroid tissue.
A systematic study of antibodies directed against thyroglobulin on one side, and against microsomes on the other side, was made during two consecutive years on a hospital population of out patients supposed to suffer from a thyroid affection: about one fourth of the serums is positive for at least one of the two antibodies; the benefit of searching antimicrosomal antibodies is capital, but the simultaneous research of thyroglobulin antibodies is necessary. The consequences of this screening are developed in three main pathologic fields: hypothyroidism (real frequency of Hashimoto's disease in spontaneous myxodema); hyperthyroidism (prognostic implications of antibodies presence); normothyroid subjects (screening of clinical thyroid abnormalities).