A fifth locus for otosclerosis, OTSC5, maps to chromosome 3q22-24.
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Biomedical subjects
Publications and source records attributed to M Thys.
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A multiple choice questionnaire was submitted to medical technologists in three medical laboratories, at varying times after obtaining an EN 45001 accreditation. A large majority (85-90 per cent) considered that their workload was increased by the accreditation process. In two laboratories, the technologists did not think that the accreditation process had improved the quality of the results. The major advantages were the fact that everything was traceable, that the technologists felt more sure about the procedures to follow, received more responsibilities and had a better knowledge of the tests they performed. The major disadvantages were the increased paperwork, discrepancies between the procedures and the reality, the fact that more attention is paid to the formalities than to the quality of the results and that the accreditation process decreased the adaptability. The number of advantages mentioned seemed to increase with the interval since the accreditation. A small majority of the technologists preferred working in an accredited laboratory than in a non accredited one.
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The effect of post preparation on the apical seal of endodontically treated specimens was studied. The canals prepared in bovine bone were instrumented and obturated using five obturation techniques: the silver point technique, the lateral condensation of gutta-percha technique, the warm vertical condensation of gutta-percha technique, the Hygenic Ultrafil injection system and the Obtura technique. In addition to these five control groups, the five experimental groups were also subjected to post preparation. In the latter group, the gutta-percha was removed with an engine-driven root canal reamer 48 hours after obturation. Both the control and experimental groups were suspended in a 0.5 per cent crystal violet solution for 48 hours. After dye penetration, the specimens were immersed in liquid nitrogen and then split longitudinally. Linear measurements of the resultant apical dye leakage were determined by image processing. For each obturation technique, all specimens in both the control and experimental groups were recorded if they showed leakage. Using Fisher's exact probability test, it was shown that there was no significant difference between the obturation techniques used.
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