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Biomedical subjects

M Tolarová

Publications and source records attributed to M Tolarová.

At least 19 recordsLinked to original sources
PubMed1987

Orofacial clefts in Czechoslovakia. Incidence, genetics and prevention of cleft lip and palate over a 19-year period.

The precise value of incidence was calculated based on the sample of 3,660 probands with orofacial clefts born in Bohemia between 1964-1982, as all cases born in this region and time were registered. For non-syndromic cases, the incidence of cleft lip was 0.4396 per 1,000 live birth, 0.7684 for cleft lip and palate and 0.6024 for isolated cleft palate. The sample of 4,950 of our older probands born between 1886-1963 was added and the whole sample of 8,250 individuals was evaluated with respect to sex-ratio, laterality, clinical severity, seasonal incidence and age of parents. The risk of recurrence and value of heritability were calculated as well. Based on these evaluations, a four-threshold multifactorial model for cleft lip and palate was suggested and also confirmed by our results of primary prevention of orofacial clefts using periconceptional supplementation with vitamins and folic acid.

Cleft Lip↗
PubMed1981

Iodine metabolism in mothers of children with cleft lip and/or palate anomaly and in persons with endemic goitre.

The authors examined 106 subjects with simple goitre and 18 hyperthyroid subjects who themselves or their ancestors came from endemic areas, furthermore 31 mothers of children with cleft lip and/or palate and 50 subjects acting as controls. The biochemical indicators in endemic goitre were at the borderline of hypothyroidism, in mothers of children with clefts on the borderline of hyperthyroidism. The authors conclude that genetically conditioned endemic mild thyroid hypofunction still persists in our population nad that it must be taken into consideration during the examination and treatment of thyropathies. The thyroid metabolism of mothers of children with cleft lip and/or palate differs significantly in many indicators from the endemic group and preconceptional and early prenatal prevention should be focused on elimination of possible marginal hyperthyroidism. The necessity to examine the thyroid metabolism of the mother as part of preconceptional genetic care was confirmed by these results.

Adult↗