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Biomedical subjects

M Tomsová

Publications and source records attributed to M Tomsová.

9 recordsLinked to original sources
PubMed2006

[Lipomatous hypertrophy of the cardiac interatrial septum].

Lipomatous hypertrophy of the interatrial septum (LHIS) is a rare lesion of unknown origin usually diagnosed as an incidental finding during autopsy. It can be associated with supraventricular arrhythmias, venous return obstruction and sudden cardiac death. Five necropsy cases (4 females, 1 male) of LHIS were encountered during the last 31 years; only one case from this series was diagnosed ante mortem. The patients' mean age was 68 years; their mean BMI was 28.4. The mean size of the lesion was 31 mm. In three patients the LHIS was asymptomatic, two patients experienced relapsing multifocal atrial tachycardia and sick sinus syndrome, respectively. Histologically, all cases consisted of a mixture of mature and brown adipose tissue with foci of cardiomyocytes. For a pathologist the knowledge of LHIS is important because of an increasing possibility of its ante mortem diagnosis by imaging methods with a following endomyocardial biopsy, and also because it may appear as a cause of sudden cardiac death.

Adipose Tissue↗
PubMed2005

[Prognostic markers in ovarian carcinoma--retrospective study].

Ovarian carcinoma is one of the most common cancers in women. The high mortality is due mostly to the fact that the tumour is frequently diagnosed in advanced stages. The aim of our study was to find immunohistochemically detectable significant prognostic markers for invasive ovarian carcinoma. There were two areas of research: the expression of hormonal receptors by tumour cells, and the examination of proliferation activity of the tumour cell by means of antibody Ki-67. Tumour samples from 96 patients with carcinoma of ovary were evaluated (age 27-82 years, mean 55.2 years). Size of residual tumour (p = 0.00002), FIGO stage (p = 0.001), age (p = 0.018), expression of progesterone receptors (p = 0.004), coexpression of steroid receptors (p = 0.039), proliferation activity of the tumour cell (p = 0.04), and chemotherapy (p = 0.018) were significant predictors of survival in univariate analysis. Borderline significance was found in other evaluated parameters: grade (p = 0.063) and histology of carcinoma (p = 0.085). Expression of estrogen receptors and radiotherapy were not correlated to survival in univariate analysis. Multivariate analysis revealed that only clinical parameters were significant prognostic factors: size of residual tumor (p < 0.0000), chemotherapy (p = 0.0009), radiotherapy (p = 0.0097), and age (p = 0.0048).

Adult↗
PubMed2005

[Small bowel carcinoid].

Tumors of the small intestine can be fatal from the oncologic point of view. Its quite sporadic incidence and absence of early clinical symptoms lead to its very difficult diagnosis. Carcinoid stays as the second most often tumor of the small intestine and it is qualified by some authors as semimalignant. The case report presented is aimed at that issue.

Aged↗
PubMed2003

[Serous microcystic adenoma of the pancreas: cytologic and histologic features].

Cytologic and histologic features in a case of serous microcystic adenoma of the pancreas in a 61-year-old female are presented. In fine-needle aspiration materials, epithelial cells arranged singly, in small clusters and in monolayer sheets were found. The neoplastic cells had round to oval nuclei with finely distributed chromatin and inconspicuous nucleoli. Nuclear atypia and mitoses were not seen. The cytoplasm was moderately abundant and finely granular. Histologically, the encapsulated tumor was composed of multiple small cysts lined by a single layer of flat to cuboidal cells. The tumor cells contained clear cytoplasm with glycogen and centrally located round to oval nuclei with inconspicuous nucleoli without any atypia. Mitoses were absent. The intervening stromal septa were hypocellular. Immunohistochemically, the tumor cells revealed diffuse positivity of cytokeratins and epithelial membrane antigen. Proliferative antigen Ki-67 was positive only in sporadic cells. No immunoreactivity for vimentin, carcinoembryonal antigen and S-100 protein was found. Chromogranin A and synaptophysin were expressed only in Langerhans' islets in the tumor capsula. In differential diagnosis, it is important to distinguish serous microcystic adenoma mainly from lymphangioma, cavernous hemangioma, serous cystadenocarcinoma, mucinous cystadenoma or cystadenocarcinoma, solid and pseudopapillary epithelial tumour, acinar cell cystadenocarcinoma, renal cell carcinoma and mesothelioma.

Adenoma↗
PubMed2002

[Solid and papillary epithelial tumor of the pancreas: cytologic and histologic features].

Cytologic and histologic features in a case of solid and papillary epithelial neoplasm (SPEN) of the pancreas in a 34-year-old female are presented. In the fine-needle aspiration material, there was a predominance of pseudopapillary fragments with delicate fibrovascular core lined with one or more layers of uniform tumor cells with clear cytoplasm. There were also acinar-like or rosette-like structures and dispersed tumor cells. Tumor cells had small, round to oval nuclei, with finely granular chromatin and inconspicuous nucleolus. Rarely, nuclear grooves were present. Mitoses were not seen. Histologically, the encapsulated tumor was predominantly solid, with focal pseudocystic and pseudopapillary areas; foreign body granulomas were focally present. Tumor cells were small and uniform with clear cytoplasm. Mitoses were extremely rare. Immunohistochemically, the tumor cells revealed diffuse positivity of vimentin, and focal positivity for alpha 1-antitrypsin and CD68. No immunoreactivity for chromogranin, synaptophysin, cytokeratin, HMB 45, estrogen and progesterone receptors was found. In differential diagnosis, it is important to distinguish SPEN mainly from mucinous tumors of the pancreas, microcystic adenoma and pseudocysts, but also from endocrine tumors of the pancreas, acinic cell carcinoma, renal cell carcinoma, adrenal cortical adenoma and primary extrapulmonary sugar tumor.

Adult↗
PubMed2001

[Mycotic diseases of the heart].

There has been an increasing frequency of deep mycotic infections over the last years complicating mostly disease states with immunosuppression. During the last 30 years, 54 cases of mycotic infection of the heart were identified at the Fingerland Department of Pathology in Hradec Králové, with 32 cases during the last 10 years alone (prevalence 0.2% of 28 199 autopsies). A review of the sex, age, etiology, source of infection, principal disease and morphological cardiac findings is presented. There was male predominance (74%). The mean age of the patients was 48 years (ranging from 15 days to 87 years). Yeasts of genus Candida dominated, followed in incidence by genus Aspergillus. The postmortem haemocultivation was positive in only 25% of all cases, while cultivation from a vegetation or a myocardial abscess was positive in 61%. The probable source of infection was detected in 28 patients; very often it was bronchopneumonia or an infected central venous catheter. Endocarditis was found in 28 cases, including six cases on a prosthetic valve and four cases on mural endocardium. Isolated myocarditis was found in 25 patients. There was also one case of isolated mycotic pericarditis. In more than half of all patients there was a state of immunosuppression, usually caused by a haematologic malignancy.

Abscess↗
PubMed2000

[Cardiac myxomas].

Cardiac myxoma is the most common primary tumor of the heart. Between 1970 and 1998, 33 myxomas from patients operated at the Cardiosurgical Department were submitted for pathological examination. A review of age, sex and clinical symptoms of the patients as well as of gross and histological features of the tumors is presented. Immunohistochemical examination was performed on 10 selected myxomas-reactivity to vimentin, desmin, S-100 protein, cytokeratin and FVIIIR-Ag. The necessity of histological examination of the embolectomy material is stressed.

Adult↗