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Biomedical subjects

M Tonelli

Publications and source records attributed to M Tonelli.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Association of primary malignant neoplasms in the same patient].

The Authors have examined the problem concerning the presence of "Double malignancies" in the same patient, on the basis of a review of the literature and of an investigation of their own case material (nine patients: six with double solid tumours and three with a solid tumour and an associated haematologic neoplasia). The Authors discuss the time sequence of the two neoplastic processes and the immunological pattern (T and B lymphocytes) of all cases.

Adenocarcinoma↗
PubMed1980

Autoradiographic studies on lymph node populations from non-Hodgkin B lymphomas.

The authors have investigated the cytokinetic behaviour of 23 cases of non-Hodgkin B cell lymphomas. In all cases diagnosis was established on the basis of histological, cytoimmunological and cytochemical data. The study, carried out with the aid of autoradiographic techniques, indicates that the various histological subclasses are characterized by a different metabolic and kinetic behaviour: the aggressiveness of the malignant lymphoma is closely related to the rate of growth of the lymphomatous cell populations, as assessed by the mitotic index and the labelling index with 3H-thymidine. The study of the synthesis and metabolism of RNA provides not only useful information on the energy requirements necessary for the neoplastic growth, but, when employed in association with immunohistochemical techniques for the detection of intracytoplasmic Ig synthesis, it defines more accurately the functional characteristics and the differentiation potentialities of the neoplastic populations in different cases.

Aged↗
PubMed1979

Aortic root motion for the assessment of left ventricular function in acute myocardial infarction.

In a group of patients with various cardiac disorders positive correlation between aortic root motion amplitude and stroke volume was observed: (y=3.41 + 0.061 chi, r=0.719n=27), where y is the aortic wall motion amplitude in mm and chi is the stroke volume in ml. During the serial investigation of 40 patients with acute myocardial infarction aortic root systolic motion amplitude was significantly different between patients groups, selected by the categories of Killip (1967). Biggest amplitudes were found in patients with complicated course, smallest amplitudes in cardiogenic shock. Aortic root systolic motion increased in a parallel direction with the clinical improvement of the patients. Aortic root echos are easily detectable, independent from segmental dysfunction, therefore useful in monitoring of left ventricular function of patients with acute myocardial infarction.

Acute Disease↗
PubMedDate not supplied

Access type as a predictor of dialysis adequacy in chronic hemodialysis patients.

Dialysis prescription commonly exceeds the delivered dialysis dose. Tunneled hemodialysis catheters (PC) may provide less dialysis than arteriovenous fistula (AVF) and polytetrafluoroethylene grafts (GG), but the impact of access type on the discrepancy (deltaHD) between dialysis prescription and dose is unknown. This study investigates the relationship between deltaHD and vascular access type. Fifty three chronic hemodialysis patients in our unit were prospectively studied for 3 weeks with measurement of delivered single pool and prescribed Kt/V(urea). There were 25 patients with AVF, 17 with GG, and 11 with PC. Demographic characteristics did not significantly differ between groups. Mean prescribed Kt/V(urea) was 1.73 +/- 0.26, and mean delivered Kt/V(urea) was 1.61 +/- 0.26. For 10 of 53 (19%) patients, dialysis delivery was at least equal to that prescribed, and this proportion did not differ between access types. Forty six of fifty three patients (86.7% of all patients) received Kt/V(urea) > 1.3, with no difference in this proportion between access types: AVF 22 of 25 (88.0%), GG 16 of 17 (94.1%), PC 8 of 11 (72.7%). Surprisingly, prescription times for patients with PC (3.6 +/- 0.3 hr) were significantly shorter than for those with AVF (3.9 +/- 0.3 hr) and GG (3.9 +/- 0.3 hr) (p = 0.02), perhaps indicating physician bias toward patients with tunneled catheters. In summary, access type was not a significant predictor of deltaHD, although patients with arteriovenous access tended to receive more dialysis than those with tunneled catheters. While a large proportion of patients received less dialysis than prescribed, the high levels of delivered Kt/V(urea) indicate that adequate dialysis is possible even in patients who must use tunneled catheters.

Adult↗