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Biomedical subjects

M Torten

Publications and source records attributed to M Torten.

At least 37 records · Page 2Linked to original sources
PubMed1975

Myocardial sparing effect of fentanyl during halothane anaesthesia in dogs.

The cardiovascular effects of fentanyl (Sublimaze) were studied in seven mongrel dogs. A constant infusion of the drug was used to produce an apnoeic end-point while concomitant cardiovascular changes were monitored. After one hour the infusion was repeated while ventilation was controlled and atropine was given to eliminate the haemodynamic effect of changes in PaCO2 and heart rate. When PaCO2 was allowed to increase fentanyl reduced heart rate and mean arterial pressure markedly while left ventricular dp/dt was depressed moderately at the time of respiratory arrest. When heart rate and PaCO2 were kept constant there was little variation in the cardiovascular measurements during fentanyl infusion. We conclude that fentanyl allows relative myocardial sparing in dogs when used at clinically effective concentrations.

Anesthesia, Inhalation↗
PubMed1975

Immune plasma-dependent cytotoxicity of immune and non-immune peripheral lymphoid cells for target cells coated with bacterial outer unit membrane.

The development of a model system for use in the study of lymphoid cell cytotoxicity to bacterial membrane antigens was attempted. In this system 51 Cr-labelled chicken red blood target cells were coated with pieces of the outer unit membrane of leptospirae rather than with soluble antigens. Using the model system to study dog peripheral immune lymphoid cell cytotoxicity to coated target cells we found that both immune and non-immune lymphocytes are antibody dependent for the expression of their cytotoxicity. It was also found that the unit membrane preparation from leptospirae can serve as a good antigenic stimulant to immune dog lymphoid cells as measured by increased [3H]thymidine uptake.

Animals↗
PubMed1975

Isolation of a 'saprophytic' leptospiral serotype andamana from carrier rats in Israel.

The first isolation of two leptospira strains belonging to the serotype andamana from the kidney of Rattus norvegicus is reported. A strain of this serotype has never before been isolated in the Middle East, nor from any rodent in any other part of the world. Its epidemiologic significance and the classification of this serotype as part of the saprophytic Biflexa species is discussed.

Animals↗
PubMed1975

Antibodies to fentanyl.

Immunization of rabbits with carboxyfentanyl-bovine gamma-globulin conjugate induced antibodies of high titers capable of binding with fentanyl. The antibodies exhibited high average association constants (approximately 1 times 10-7 liter/mol) and were highly specific to fentanyl since no cross-reactivity was observed for a variety of test compounds including other opiates and analgesics. Serological cross-reactivity was observed only for chemicals representing various portions of the fentanyl molecule. These high-affinity, highly selective antibodies have been successfully employed in a radioimmunoassay for fentanyl. Serum concentrations of fentanyl, after administration of 100 and 21 mug/kg/ i.v. in dogs, were determined by this radioimmunoassay. The specificity of these antibodies as compared with the specificity of the pharmacological (opiate) receptor is also discussed.

Animals↗