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Biomedical subjects

M Toyohara

Publications and source records attributed to M Toyohara.

At least 19 recordsLinked to original sources
PubMed1995

[Combination therapy of high dose 5'-DFUR+MMC for advanced or recurrent gastric cancer. 5'-DFUR Joint Research Group in the Osaka District for Gastric Cancer].

We conducted multi-center clinical trials of 'Treatment with high dose 5'-DFUR+MMC' in order to evaluate the effects, the possibility for outpatient treatment and the survival effects in patients with advanced or recurrent gastric cancer. The treatment schedule was as follow; 5'-DFUR 1,600 mg/body/day was given orally for five consecutive days every week and MMC 6 mg/m2 was injected intravenously once every four weeks. Forty-eight patients were enrolled and 34 cases were evaluated for anti-tumor responses. The overall response rate was 29.4% (10/34 cases). Side effects were mainly diarrhea, but outpatient treatment was possible in most cases. The median survival period was 249 days, which is longer than with other treatments. This result suggests that this combination chemotherapy is useful in patients with advanced or recurrent gastric cancers.

Adult↗
PubMed1991

Experimental study on the relapse of tuberculosis after the termination of antituberculous chemotherapy using immunodeficient nude mice.

The effect of cellular immunity induced by tuberculous infection on bacteriological relapse after the termination of antituberculous chemotherapy was studied experimentally using immunodeficient nu/nu mice and immunocompetent dd mice. The efficacy of intensive chemotherapy was excellent even in nu/nu mice; tubercle bacilli in the organs decreased below the detectable limit, but formidable regrowth of bacilli was seen after the termination of chemotherapy. On the other hand, in the case of dd mice that established antituberculous cellular immunity through tuberculous infection, bacteriological relapse was generally very slight. It was concluded that bacteriological relapse was related closely with the established cellular immunity induced by the infected tubercle bacilli.

Animals↗
PubMed1980

[Study of lymphocytes blast transformation method by a small amount of whole blood cultivation with 125I-UdR (author's transl)].

Lymphocytes blast transformation method by a small amount of whole blood cultivation with 125I-UdR was studied. 1) It is suitable to take for 4 or 5 days as culture days. 2) It is suitable to add PHA-P in the concentration of 7.5 micrograms per ml of medium. 3) Addition of fetal calf serum in medium is not required. 4) The mean value of SI was 35.62 for the healthy persons, 31.23 for the patients of lung tuberculosis and 16.31 for the patients of lung cancer. The difference of SI between the healthy persons and the lung cancer was significant statistically.

Cells, Cultured↗