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Biomedical subjects

M Traisnel

Publications and source records attributed to M Traisnel.

At least 19 recordsLinked to original sources
PubMed2002

Electrochemical and cytocompatibility assessment of NiTiNOL memory shape alloy for orthodontic use.

Orthodontic arcs and wires are mostly realised from alloys and constitute the motor of dental shifting. Ti-base alloys rapidly replaced the formerly used stainless steel wires due to their excellent corrosion resistance, their high mechanical characteristics and their increased biocompatibility. NiTiNOL shape memory alloys add to these advantages their ability of deforming force. NiTiNOL, highly pure Nickel (hp-Ni) and commercially pure titanium (cp-Ti) were tested by electrochemical assays in artificial saliva and in vitro biological tests with L132 cells and HEPM cells. All tests gave concordant results: the electrochemical assays, the proliferation test, the colony forming method, and the inflammatory test clearly show, that nickel is a corrosive and a cytotoxic material. Ti and NiTiNOL are cytocompatible and in particular corrosion resistant. No significant differences are observed for both materials on the electrochemical and the biological level as well. The NiTiNOL shape memory alloy is a master trump for dental practitioners to repair occlusal defects by shifting teeth under optimal biological conditions. In spite of its high Ni-content, it is biocompatible. It considerably reduces the tune of therapeutic treatment, facilitate the occlusal concept and leads to a result of high clinical quality.

Alloys↗
PubMed1997

[The electrochemical behavior of TiTa30 and TiNb30 alloys for implantology].

The electrochemical behavior in artificial saliva of TiNb30 and TiTa30 alloys were compared with that of commercial pure titanium. The anodic potential, the current density, the passivation potential and the galvanic corrosion vs. Au were determined. Both alloys have a similar behavior to that of pure titanium. Crevace corrosion, which is very weak in pure Ti, is completely inhibited by the addition of Nb or Ta.

Alloys↗
PubMed1994

[Pharmaceutical technology: development and research].

Production of pharmaceutics cannot be compared to the manufacture of consumer goods: pharmaceutical manufacturing is the study and bulk manufacture of the ingredients from which medicines are made, and is concerned with the mixing, preparing, packing, of the ingredients into a dosage form for the patient, in according to the good manufacturing practices (GMP). Development and manufacture are not discrete activities but links in a single chain of activity. Research and development, pharmaceutical training, regulatory requirements: these concepts are present with three ways: bioavailability, targeting and compliance.

Dosage Forms↗
PubMed1992

[HPLC used in the validation of simple methods for research of degradation products in essential drug tablets].

HPLC have been used to validate simple methods to be employed in developing countries (DC) for the quality control of drugs. As the important lack of analytical material in DC, colorimetric methods have been used. These are subjected to visual appreciation of the color intensity. Two essential drugs have been selected: aspirin, hydrochlorothiazide. For each compound, standardization of concentration's degradation product by colorimetry and HPLC have been achieved in proximity of the restricted norms of pharmacopoeia. These results have been applied to tablets exposed to stressed conditions (t(0) = 60 and humidity = 75%). The results obtained by colorimetric method were similar to HPLC's ones.

Aspirin↗
PubMed1990

Corrosion of surgical implants.

Corrosion on orthopaedic implants has been studied. Twelve intramedullary nails and twelve osteosynthesis plates were implanted up to eight and thirteen years, respectively. Analysis of biological fluids from all patients was carried out and revealed high concentrations of nickel and chromium that correlated to the implantation time. All implants were corroded by both crevice and intergranular corrosion. Intergranular corrosion is related to mechanical and heating treatments. Crevice-like corrosion is probably enhanced by sulphur present in amino-acids. Electronic probe analysis shows the reaction study between both sulphur and nickel and sulphur and chromium. These results are compared to the metal distribution in body fluids. After a certain incubation time the corrosion accelerates as is characteristic for crevice-like corrosion processes. Studies of the distribution rate of two Ni-Fe-Cr dental alloys in a cell culture system give similar results: metal-ion release increases with the exposure time.

Bone Nails↗
PubMed1990

[Non-destructive quality control of tablets by photoacoustic infrared spectrometry. Analysis in primary packaging].

We have studied the feasibility of the photoacoustic detection in Fourier transform infrared spectrometry for the quality control of drug tablets. Beyond the non destructive character of the method, the main advantage which has been established is the precocity of impurity detection on the tablet outside. The direct recording of spectra through PVC lead to interesting results for study of tablets under blister.

Drug Packaging↗