PubMed Health⌕ Search

Biomedical subjects

M Troncoso

Publications and source records attributed to M Troncoso.

26 records · Page 2Linked to original sources
PubMed1983

Enteropathogen carriage by healthy individuals living in an area with poor sanitation.

Faecal carriage of bacterial enteropathogens (enteropathogenic Escherichia coli (EPEC), shigellae and salmonellae) was studied in 265 individuals: 65 infants 3-6 months of age (50 bottle-fed and 15 breast-fed), 100 school-age children 8-10 years of age and 100 adults 21-50 years of age. All were apparently healthy, did not have gastrointestinal symptoms, had not received antibiotics in the preceding fortnight and were not malnourished. Enteropathogens were isolated from the faeces of 24 individuals (9.1%). Cultures were positive for enteropathogens in 20% of the infants (both breast- and bottle-fed), 8% of school-age children and 3% of the adults. EPEC was the most frequent isolate. Twelve different serotypes were detected. The highest recoveries were E. coli 026:K60 and 044 . K74. Shigella was detected only in school-age children (2%) and salmonella only in adults (1%). Campylobacter jejuni and Yersinia enterocolitica were studied only in the school-age children: there was one isolate of each of them. Most enteropathogens isolated were susceptible to the majority of the antibiotics tested. Only four E. coli strains, isolated from bottle-fed infants, could be considered multi-resistant. Two of the strains wer E. coli 044:K74 and 020a020c:K61. The remainder were E. coli 0111:K58 and wee capable of transferring some of their antibiotic resistance traits to a recipient strain.

Adult↗
PubMed1983

[Nutritional impact of supplemented food in relation to the duration and severity of infectious episodes].

The nutritional impact of three different programs of supplementary feeding implemented with children aged 6-24 months, was examined in relation to the duration and the severity of infectious diseases. After a 2-month intervention, statistically significant changes in weight for length were found in two of the groups (those supplemented with rice and beans, and those supplemented with rice cereal enriched with oil). No significant changes in weight for length were found in the other groups (those supplemented with banana cereal and the control group), nor were statistically significant changes found in any of the four groups in relation to weight for age, nor length for age. No statistically significant changes were found on the incidence, duration, and severity of infectious diseases. As a result of these findings it can be postulated that despite a high frequency of infectious episodes, often severe and of long duration, supplementary feeding on the early part of life can be effective when there is a high risk of malnutrition.

Anthropometry↗
PubMedDate not supplied

[Treatment of massive spasms with synthetic ACTH].

Ten infants with infantile spasms (IS) and hypoarrhythmic EEG, received 0.5 mg i.m. of synthetic ACTH, three times a week for 2 weeks. Six of them showed complete remission of seizures and dramatic EEG changes, and 3 cases resulted in a partial response. Spasms were controlled during the first week in 5/6 cases where treatment was successful. A significant relationship was observed between treatment precocity and favourable outcome (Fisher p < 0.02). Synthetic ACTH treatment did not produce severe side effects in any patient. During follow up (X 6.2 m) relapse occurred in one case, with 5 patients maintaining the initial positive response and a normal or mildly retarded psychomotor development. The other five patients show severe psychomotor retardation and intractable spasms and/or other seizures. Future research should focus on the efficacy of other treatment schedules, equilibrating success and side effects.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Etiologic research in massive spasms].

A systematic clinical protocol was applied in 16 infants that suffered from infantile spasms (IS) in order to identify etiologic factors. A positive family history was present in 2/16 patients and relevant perinatal or postnatal pathology in 5/16. Psychomotor retardation and other seizures anteceded IS in 10/16 and 8/16 infants respectively. Physical and neurologic examination revealed microcephalia (4/16), dysmorphic features (2/16), hypopigmented skin lesions (1/16) and pyramidal syndrome (8/16). Neuroimaging technics yielded positive findings in 9/16 patients, diffuse or localized atrophy (7/16), porencephalic cysts (3/16), periventricular calcifications (1/16), callosal agenesis (1/16). Laboratory examination allowed diagnosis of two metabolic diseases: congenital hyperlactatemia an maple syrup urine disease. Two patients were classified as cryptogenetic and fourteen as symptomatic. Within the latter an etiologic factor was identified in 12/14. This study underlines the value of etiologic search in IS, because it may contribute substantially to specific treatment and genetic counselling.

Clinical Protocols↗
PubMedDate not supplied

[Intestinal pneumatosis].

Fourteen cases of intestinal pneumotosis were found in a review of 1 477 plain abdomen X-ray films taken because of different conditions. These 14 cases were associated in most instances with septicemia, gastroenteritis and paralytic ileus. The mortality was high. The treatment should be directed to the management of the primary condition: intestinal pneumatosis, septicemia, gastroenteritis, paralytic ileus.

Child↗