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Biomedical subjects

M Ujec

Publications and source records attributed to M Ujec.

29 records · Page 2Linked to original sources

[Favorable course of pregnancy in a patient two years after kidney transplantation].

A 30-year old female underwent kidney transplantation after unsuccessful 3-year dialysis for renal cortex necrosis. Immunosuppression was achieved with cyclosporin followed by azathioprine with prednisone. The patient conceived after 22 months with kidney transplantation. Mild decrease in arterial blood pressure and marked increased in glomerular filtration rate were seen during the first three months of pregnancy. Arterial blood pressure increased but insignificantly at the end of pregnancy. That time, gradual decrease in creatinine clearance was observed. An increase in serum bilirubin and alkaline phosphatase was noted. Pregnancy was terminated by cesarean section on the 38th week. Newborn was female, full-termed, viable, with body weight of 3,300 g. All examined parameters were normalized after delivery. Described case indicates that transplanted kidney functioning during pregnancy is similar to that in healthy women.

Adult↗

[Diagnostic value of determining alpha1 protease inhibitor and alpha2 macroglobulin in the serum of women with malignant and non-malignant ovarian tumors and uterine myomas].

In the serum of 21 women with malignant ovarian tumours, 13 with uterine myomas and 16 with cysts the concentrations were determined of alpha 1 inhibitor of proteases and alpha 2 macroglobulin by immunodiffusion, and the functional activity of both inhibitors which made possible calculation of the specific activity (units of inhibitory activity per one gram of inhibitor protein). In women with malignant tumours the specific activity of alpha 1 inhibitor was decreased, suggesting that a part of the inhibitor was functionally inactive. This decrease was statistically significant in relation to the control group and the groups of myomas and cysts, but was independent of the degree of disease progression. The specific activity of alpha 2 macroglobulin was significantly decreased only in patients with grade IV degrees of clinical progression (according to FIGO) in relation to the control group and to the group with cysts.

Adolescent↗

[Ulcerative colitis and pregnancy].

On the basis of literature and on the grounds of their own experience the authors presented their opinions on the coexistence of colitis ulcerosa (c.u.) and pregnancy. It was stressed that colitis ulcerosa does not decrease fertility in women whereas the taking of salazosulfapyridine diminishes fertility in men. Pregnancy should be planned during the remission period. Successive pregnancies in the same patient with coexistent c.u. should be taken individually. Classic pharmacotherapy end endoscopic diagnostics are not contraindicated in pregnancy. Past operation (e.g. partial or total colectomy) do not decrease chances of giving birth to a child. There is no evidence that artificial abortion exerts a favourable influence on the course of colitis ulcerosa. Cesarean section should be performed of obstetrical indications only. In addition, the authors emphasize the necessity of a strict monitoring of c.u. in the first trimester of pregnancy and during puerperium, as well as of a rigorous gynecological supervision in the third trimester of pregnancy.

Colitis, Ulcerative↗