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Biomedical subjects

M Ujpál

Publications and source records attributed to M Ujpál.

15 recordsLinked to original sources
PubMed2005

The prognostic role of clinical, morphological and molecular markers in oral squamous cell tumors.

Despite of considerable advances in the diagnostic and therapeutic possibilities, the prognosis of epithelial tumors in the oral cavity is still very poor. A knowledge of the prognostic factors at the beginning of treatment is therefore indispensable for determination of the appropriate therapy for the given patient. These factors may be linked to the patient (e.g. age, sex, general condition and immunological parameters) or to the tumor localization. A survey of the literature reveals that the TNM stage, the grade, the mode of invasion and the depth of the tumor infiltration are generally the most important factors influencing the fate of the patient. The prognosis depends primarily on the clinicopathological parameters, though even if they are known, it is not possible to screen out those patients who are at particular risk of a relapse. During the past 10 years, study of the DNA content distribution, the proliferation markers and certain oncogenes has come into the focus of attention; great interest is also shown in the extracellular matrix components and the metalloproteinases, which play key roles in the invasion and metastasis formation.

Biomarkers, Tumor↗
PubMed2003

Malignant myoepithelioma. Clinicopathological and immunohistochemical characteristics.

A malignant myoepithelioma arising in the submucosal accessory glands of the oral cavity of a 23-year-old woman is reported. The patient was very young compared to the cases in the literature, and the tumour had an unusual vestibular location. A false diagnosis of pleomorphic adenoma had been made by fine needle aspiration biopsy. The surgery comprised a wide tumour excision, but neck dissection was not indicated. The final histologic diagnosis was malignant myoepithelioma. Immunohistochemically putative myoepithelial markers were highly expressed.

Actins↗
PubMed2003

Resection and replacement of the carotid artery in metastatic head and neck cancer: literature review and case report.

Metastases of advanced tumours of the oral cavity sometimes affect the cervical segments of the carotid arteries. The situation is worse in the 5-10% of cases in which the metastasis involves the common or internal carotid to such an extent that resection and replacement of the artery become necessary. Following clinical, CT/NM, and angiographic examinations, a surgical plan for the resection and reconstruction of the affected vascular segment is formulated. In preparing a treatment plan, emphasis must be placed on the expected quality of life, and careful consideration must be given to the extent of the operation.A survey of the international literature reveals that the reported mean 1-year complaint free survival rate after resection and reconstruction varies between 0 and 44%. In our experience, the wall of the carotid vessels is very resistant to tumour invasion in a large majority of patients. When radical surgery and reconstruction are carried out in the same session, does this increase the long-term cure rate and lengthen patient survival? A number of authors agree that radical interventions do not alter the survival indices significantly, but may improve the quality of life and regional control of the disease. The controversy over this topic is illustrated by means of a case report.

Blood Vessel Prosthesis↗
PubMed2002

Quadruple cancer, including triple cancers in the head and neck region.

Multiple primary tumors are not rare: they are encountered in 3-5% of malignant tumors. They are particularly frequent in the head and neck [20]. They are most often met with secondary malignant tumors; triple tumors occur in only 0.5%, quadruple tumors in 0.3% of malignant tumors. The possibility of developing a second metachronous cancer 5 years after undergoing treatment of the initial head and neck cancer is approximately 22%. Multiple metachronous tumors often appear 3-4 years after the observation of the primary tumor, or even after 5-10 years in the case of laryngeal tumors. The frequency of multiple primary tumors in the head and neck region supports the "field cancerization" theory, according to which the inducing agents (primarily smoking and alcohol consumption) can initiate the tumorous degeneration at a number of sites in the oropharyngeal region. The authors report on a case in whom surgery for bladder tumor was followed 101 months later by tumor development in the region of the head and neck: 3 such tumors were treated within a period of 21 months. The histologic result on the bladder tumor was transitiocellular carcinoma, while the latter ones were squamous cell carcinomas. Three of the tumors were treated effectively (no local recurrence or metastasis developed), but the fourth led to the death of the patient. The literature on multiple tumors of the head and neck is reviewed, and possible etiologic factors are discussed. It is pointed out that, besides primary and secondary prevention, close observation of these patients is required, repeated panendoscopy of the upper aerodigestive tract and genetic examinations are recommended.

Carcinoma, Squamous Cell↗
PubMed2001

Long-term results following surgical treatment of benign symmetric lipomatosis (BSL).

Benign symmetric lipomatosis is a rare disease. Its main characteristic is the symmetric deposition of fat, in an unencapsulated form, at typical sites in the body, but primarily in the head and neck region. Its aetiopathogenesis is unknown. A disturbance of lipid metabolism is involved, and there is a proven connection with chronic alcoholism. Problems with the differential diagnosis of the characteristic clinical picture arise from the fact that this disease is not widely recognized. Over a period of 30 years, the authors treated 31 patients with benign symmetric lipomatosis. They review the pertinent literature and report retrospectively on the fates of the 11 surviving patients.

Adult↗
PubMed2000

[Gardner syndrome--on the basis of three cases].

Based on the 3 cases, the authors describe the Gardner-syndrome which is not so well-known in Hungary. The most important features of the Gardner syndrome are the malignized large intestine polyposis, the multiplex osteomies and the different skin tumours. The earliest symptoms suspecting the clinical picture, are usually dental and/or mandibular lesions. Being aware of the above mentioned facts the dentist noticing the symptoms first is highly responsible.

Adult↗
PubMed1997

[Symmetrical exostosis on the mandible].

Authors reviewed a case of a symmetric mandible-exostosis at a 16 year old man. He has been operated on account of aesthetics. The authors have found the same rare localized alteration at the grandmother too. The symmetric exostosis seems likely to be hereditary.

Adolescent↗
PubMed1994

[Experience with Otten's maxillomandibular fixation method].

The authors are reporting on a method of mandibulomaxillary fixation worked out in their institute through a modification of those defined in literature. A wire hook is fixed by a screw to the mandibula and maxilla and, by the help of it an intermaxillary fixation is formed. The procedure is simple, quickly accomplishable and cheap. Its application is recommended to be introduced for other institutes, as well.

Fracture Fixation↗
PubMed1993

[Postmortem diagnosis of primary malignant tumors in a 10-year patient material].

Dissectional data were analysed of deceased patients due of malignant tumors of the neck-head area, in the authors institute in the last ten years. Besides the fatal primary tumor in 6.1% of the cases there were clinically not, just post mortem diagnosed multiple tumors. The authors advise more thorough examination and over five years control of the patients.

Autopsy↗