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Biomedical subjects

M Ulbig

Publications and source records attributed to M Ulbig.

28 records · Page 2Linked to original sources
PubMed1991

[Absence of cataractogenic effect of lovastatin (Mevinacor) so far].

Lovastatin is an inhibitor of HMG-Co A reductase, a key enzyme in cholesterol biosynthesis. It is of therapeutic value in hypercholesterolemia type IIa and leads to decreased levels of low-density lipoproteins in serum. Treatment with high doses of lovastatin has been reported to induce cataract formation in dogs. The goal of the ongoing prospective clinical study is to evaluate whether cataract formation is caused in humans by therapeutic doses of lovastatin. So far 28 patients (average age 44 years) suffering from hypercholsterolemia have entered the study. Besides thorough slit-lamp investigations in all patients, best corrected visual acuity and contrast sensitivity for five different spatial frequencies were measured. A reduction in contrast sensitivity is a sensitive indicator for opacities of lens and cornea. During a mean follow-up of 37 weeks (range 5-62 weeks) with a mean total dose of 15 g (range 2-26 g), no cataract formation or decreased contrast sensitivity has so far been observed.

Adult↗
PubMed1991

The eye in diabetes.

Explore the source record for details and available documents.

Diabetic Retinopathy↗
PubMed1991

[Diagnostic and functional significance of arcus lipoides in hypercholesterolemia].

Twenty-eight patients were studied who required treatment for hypercholesterolemia type IIa. Familial hypercholesterolemia was found in 53%. Sixty percent of all patients had arcus senilis. When familial and non-familial hypercholesterolemia were compared the incidence of arcus senilis was 80% and 38%, respectively. The gradation of the condition was minor (n = 9), moderate (n = 4), or pronounced (n = 4); all patients with a strong degree and 7 of 8 patients with either moderate or pronounced arcus senilis had familial hypercholesterolemia. The mean cholesterol level was 345 +/- 82 in patients with familial hypercholesterolemia and 353 +/- 120 mg/dl in patients with non-familial hypercholesterolemia. Although the correlation between the cholesterol level and the degree of arcus senilis was higher in patients with familial hypercholesterolemia than in those with non-familial hypercholesterolemia (r = 0.45 versus r = 0.17), neither had clinical relevance. There was no connection between the cholesterol level, refraction or visual acuity. The mean contrast sensitivity measured for five different spatial frequencies in all patients was normal. In comparison with patients without arcus senilis, the mean values in patients with severe arcus senilis showed lower contrast sensitivity for the higher spatial frequencies.

Adult↗
PubMed1990

[Vitrectomy in proliferative diabetic retinopathy. Preoperative factors for surgical procedure and postoperative results].

In this study we evaluated the impact of preoperative factors on the choice of intraocular tamponades (balanced salt solution and gas or silicone oil) and postsurgical visual function in cases of vitrectomy for proliferative diabetic retinopathy. We studied 150 consecutive vitrectomies for proliferative diabetic retinopathy, which were carried out from October 1987 to February 1989. The extent of central or peripheral traction and retinal detachment were found to have a major influence on the choice of intraocular tamponades. Different types of diabetes, renal failure, and the time interval since the last vitreous hemorrhage showed no influence on the choice of intraocular tamponades. Visual acuity was improved after vitrectomy in the group with silicone oil tamponade, as well as in the control group with BSS or gas tamponade. Patients receiving silicone oil had more advanced stages of proliferative diabetic retinopathy and therefore more complicated postsurgical courses. Silicone oil is more likely to be avoided in cases without retinal detachment, where the risk of further vitreous hemorrhage is felt to be low and in cases with complete panretinal photocoagulation. The present study supports the therapeutic value of complete panretinal photocoagulation for proliferative diabetic retinopathy--even in cases where the proliferative retinopathy progresses and a vitrectomy is needed. It is demonstrated that many patients requiring vitrectomy did not receive sufficient photocoagulation earlier.

Adult↗
PubMed1989

[Pars plana vitrectomy in chronic uveitis in the child].

In five children aged between 8 and 14, suffering from chronic recurrent uveitis of undetermined etiology, pars plana vitrectomy was performed in order to halt progression of the disease. Postoperatively there was a clear improvement in vision in all five patients, and in the follow-up period of 5 to 26 months there were no further recurrences of uveitis in the eyes which had been treated. These observations support the assumption that vitrectomy has a favorable effect not only in adults but also in children with therapy-resistant uveitis.

Adolescent↗
PubMed1989

Fate of late complications in type I diabetic patients after successful pancreas-kidney transplantation.

The success rate of pancreas transplantation allows us to study in more detail the potential beneficial effects of normoglycemia on secondary complications in diabetes mellitus. We report a prospective follow-up (mean 26 mo) of metabolic control, neuropathy, retinopathy, and peripheral microcirculation in 31 patients with type I (insulin-dependent) diabetes (mean age 33 +/- 1 yr; mean duration of diabetes 21 +/- 1 yr) after combined kidney and segmental pancreas grafting. All patients had normal HbA1 levels. Glucose tolerance (GT), insulin, C-peptide, and glucagon were normal in 22 patients, and impaired oral GT with reduced insulin secretory capacity was seen in 9 patients. During follow-up, there was no deterioration of GT and insulin release. Vascular risk factors, e.g., hypertension, cholesterol, and triglycerides, decreased after grafting. Autonomic neuropathy improved clinically, and R-R variation increased significantly in 3 of 18 patients. Peripheral neuropathy improved clinically in 46% of patients and did not deteriorate in the others. Motor nerve conduction velocity increased greater than 20% in 8, less than 20% in 12, and was unchanged in 8 of 28 recipients. Most of the patients (n = 30) had pretransplant laser treatment of their advanced retinopathy. Posttransplant visual acuity improved at least more than one line in 56%, stabilized in 32%, and deteriorated in 12% of patients. Patients with functioning grafts for greater than 1 yr had no further deterioration of visual acuity. Vitreous hemorrhage frequency and severity dropped markedly from pretransplant (from 69 to 24%) 10 mo after grafting. Retinal morphology remained stable in all eyes except two.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

Functional and morphological variations of fundus flavimaculatus.

In order to investigate functional differences between fundus flavimaculatus and ophthalmoscopically similar diseases, we performed testing of spectral sensitivity, transient tritanopia, visual fields, fluorescein angiography, color vision, electrophysiological parameters, dark adaptation, cone flicker threshold during dark adaptation, and a thorough clinical investigation in five patients. Four had characteristic fundus flavimaculatus, while one patient turned out to have an atypical form. All five patients showed similar results in clinical investigations, electrophysiological data, and visual field tests. However psychophysical tests showed a number of differences in the single atypical patient. Although his ophthalmoscopic picture was not entirely typical of fundus flavimaculatus, only his psychophysical data could identify the patient as functionally distinct from the other four.

Adolescent↗