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Biomedical subjects

M Unda

Publications and source records attributed to M Unda.

13 recordsLinked to original sources
PubMed2001

Influence of sociodemographic and health status variables on the American Urological Association symptom scores in patients with lower urinary tract symptoms.

OBJECTIVES: To evaluate the relationship between sociodemographic and health status variables and the American Urological Association Symptom Score (AUA-7) because low associations between clinical measures of lower urinary tract symptoms and scores on the AUA-7 suggest that symptoms may be influenced by other variables. METHODS: Sociodemographic, clinical, and health status variables were recorded for 666 patients with benign prostatic hyperplasia (BPH). BPH symptoms were measured with the AUA-7. Bivariate and multivariate analyses were used to determine correlations between sociodemographic and health status variables and AUA-7 scores. RESULTS: BPH-related variables (clinical rating of severity, number of BPH treatments, and being scheduled for surgery) were included in the final regression model, which explained 25% of the overall variability in scores. An additional 7% of the total variability was explained by other non-BPH-related variables (educational level, presence of depression/anxiety, and pain/discomfort). CONCLUSIONS: The AUA-7 is a robust questionnaire that is little influenced by sociodemographic variables and general health status. The educational level, mood, and presence of pain/discomfort of patients should be taken into account when interpreting scores, as a combination of these characteristics could mean a difference of up to 6 points on the AUA-7.

Age Factors↗
PubMed1997

Intravesical immunoprophylaxis in recurrent superficial bladder cancer (Stage T1): multicenter trial comparing bacille Calmette-Guérin and interferon-alpha.

OBJECTIVES: To estimate and compare recurrence rates, index of recurrence, and disease-free interval in patients with superficial recurrent bladder cancer receiving bacille Calmette-Guérin (BCG) or interferon (IFN) for immunoprophylaxis. METHODS: One hundred twenty-two patients with recurrent superficial Stage pT1, grade 1 to 3 tumors were enrolled in a randomized, prospective, multicenter trial with two treatment arms of endovesical immunoprophylaxis: 150 mg of BCG versus 54 MU of recombinant IFN-alpha-2a. Administration was weekly during the first month, biweekly for 2 months, and monthly for 9 months. Both groups were similar with regard to tumor stage, grade, size, and number. RESULTS: Sixty-one patients were evaluable in the BCG group and 49 in the IFN group. Tumors recurred in 34 (69.4%) of 49 patients in the IFN group (890 months of follow-up) and in 24 (39.3%) of 61 in the BCG group (1272 months of follow-up). The total number of recurrences (28 for BCG, 47 for IFN), disease-free interval (mean 19.3 months for BCG, 15.3 months for IFN), and index of recurrence (2.2 for BCG, 5.5 for IFN) were statistically significant (P = 0.001) in favor of BCG. Progression to invasive carcinoma was similar in both study arms. Neither systemic nor local side effects were seen in the IFN group. However, the previously reported toxicity of BCG was confirmed. CONCLUSIONS: According to our trial, BCG remains the most efficacious agent for immunoprophylaxis of recurrent superficial bladder tumors.

Adjuvants, Immunologic↗
PubMed1994

[Lateral cysts of the prostate].

Description and differential diagnosis of lateral cysts of the prostate gland which during their growth may invade its central section. Most cases, sized below 0.8 cm, are diagnosed by accident. A symptomatic prostate cyst is, in fact, a very uncommon condition. Presentation of one case of prostate cystadenoma which presented as a low urinary obstruction in a middle-age adult subject.

Adult↗
PubMed1991

Hydrops fetalis and congenital mesoblastic nephroma.

The autopsy finding of congenital mesoblastic nephroma in a stillborn hydropic fetus is reported. We discuss the pathogenetic relation of both entities and summarize the optimal therapeutic attitude to follow in order to prevent this misfortunate outcome.

Female↗
PubMed1991

[Renal adenocarcinoma in adolescents].

A case of renal adenocarcinoma arising in a 18 year-old boy is reported. This is a rare entity in childhood and adolescence that displays a similar histology to the adult form. The recent literature on its clinical and pathological features is reviewed. We conclude that, despite its rarity, adenocarcinomas must be included in the differential diagnosis of solid renal masses in early life.

Adenocarcinoma↗
PubMedDate not supplied

[Bladder leiomyosarcoma: presentation of 2 cases].

We report two cases of bladder leiomyosarcoma diagnosed by histology. Total segmental cystectomy was performed in both cases because of the scant progressive nature of the disease. A follow up of 11 and 6 years, respectively, revealed no tumor recurrence or metastasis. The choice of performing a conservative or radical surgical procedure in the treatment of this tumor type should depend on the endoscopic findings as well as tumor grade and stage.

Adolescent↗
PubMedDate not supplied

[Testicular mesothelioma. Report of a case].

Contribution of one case of malignant testicular mesothelioma. A highly malignant tumour the diagnosis and specific treatment of which is not clearly defined. The correct diagnosis should be based on a series of features not only clinical (quick re-accumulation of liquid in the inverted hydrocele) but also gross (multiple paratesticular nodes) and microscopic, supported by immunohistochemical techniques. The latter is based both in ruling an adenocarcinoma out (CEA-, LeuM1-, Vimentine- to tumoral cells), and in the reactivity of more specific antigens (CAM5.2(K-8)+ and Vimentine+ to stromal cells). The choice treatment is inguinal orchiectomy with adjuvant chemotherapy. No standard chemotherapeutical approaches have been defined.

Humans↗