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Biomedical subjects

M Unda Urzaiz

Publications and source records attributed to M Unda Urzaiz.

At least 19 recordsLinked to original sources

[Socioclinical and diagnostic characteristics of prostatism in Spain at the end of the 20th century].

RATIONALE: To study sociodemographic characteristics and current diagnostic and therapeutic behaviour with Benign Prostate Hyperplasia (BPH) patients in Spain at the end of the 20th century. METHODS: Sociodemographic, clinical, therapeutic and quality of life (QoL) data from study ESECI-98, conducted in Spain (1998-1999) in patients with BPH. RESULTS: Nine hundred and forty nine patients were evaluable, with a mean (+/- SD) age of 65.6 (+/- 7.8) years, with concomitant diseases (40%), pain/discomfort (34%) and anxiety/depression (23%); QoL score (mean +/- SD) was 72.1 +/- 16.1 on a total possible score of 100. BPH diagnosis was based on symptoms (93%), digital rectal examination (93%) and abdomino-pelvic ultrasonography (76%). PSA was mentioned for the diagnosis of BPH in 54% of the patients and 77% were receiving pharmacological treatment (61% alpha-blockers) during less than 6 months (38%) or more than a year (35%). CONCLUSIONS: In this study the diagnosis of BPH was mainly based on symptoms, digital rectal examination and abdomino-pelvic ultrasonography. It is worth mentioning that PSA for the diagnosis of BPH, was used in a half of the total number of patients. Pharmacological therapy was used in 3 out of every 4 patients. Compared to a previous national study, there is a change on diagnosis and therapy of BPH.

Aged↗

[Renal-cell adenocarcinoma as an incidental finding. Its diagnosis and tumor evolution].

OBJECTIVES: We attempted to determine whether or not incidental renal cell carcinoma had a better prognosis. METHODS: We reviewed 53 cases of renal cell carcinoma that had been surgically treated over the periods 1985-1988 and 1989-1993. The form of presentation, stage of the incidental tumors, sex, compromised side and the diagnostic imaging technique utilized were analyzed. RESULTS: GI pathology most frequently led to the diagnosis of the tumor. Tumor stages were A or B with a slightly higher prevalence for the incidental tumors. However, the prognosis was not better than that of clinically suspected renal cell carcinoma. The male to female ratio was 1.17:1, the mean age was 63 years, the tumors were frequently right-sided and ultrasound was superior in the diagnosis of incidental tumors. CONCLUSIONS: No prognostic difference was observed between clinically suspected and incidental renal cell carcinoma of the same tumor stage.

Adult↗

[Trigono-cervico-prostatotomy (TCP) versus transurethral resection of the prostate (TURP). Our experience].

OBJECTIVE: Trigonocervicoprostatotomy (TCP) has been considered up to now an alternative treatment to transurethral resection of the prostate (TURP) when evaluating the size of the prostate. This paper demonstrates that endoscopic visualization is more important when choosing the surgical procedure and that both techniques can achieve satisfactory results. METHODS: The prostate volume is evaluated by ultrasound and according to the endoscopic findings, TURP or TCP is performed. The prostatic lobes are routinely biopsied if the latter procedure is chosen. RESULTS: We compared the results of 34 TCP and 30 TURP procedures using the values of I-PSS and uroflowmetry before and after surgery. In 86.2% of the TCPs and 80% of the TURPs, the patients are asymptomatic with I-PSS less than 7 and significantly improved uroflowmetry data. Biopsy disclosed adenocarcinoma in one patient submitted to TCP. CONCLUSIONS: TCP represents an alternative to TURP not only for small prostates (30 gm) but also for medium-sized prostates (50-60 gms), depending on the endoscopic findings. TCP is not indicated for lateral lobes that fall on the prostate floor. Performing a biopsy routinely in TCP does not prolong the operating time significantly and permits detecting subclinical adenocarcinoma of the prostate.

Aged↗

[Chilaiditi syndrome in the differential diagnosis of renal colic].

We report on a case of hepatodiaphragmatic interposition of the colon in a 45-year-old patient who presented at the emergency department with a clinical picture of renal colic. When making the differential diagnosis, we should take into account that the clinical picture known as Chilaiditi syndrome may mimic renal colic.

Colic↗

[Blind-ending bifid ureter associated with adult congenital hydronephrosis].

We present a case of cephalad blind-ending bifid ureter coexisting with adult congenital hydronephrosis that had not clinically manifested previously and had been incidentally detected during surgery. The possibility that both anomalies of development may be related etiopathogenically is discussed. This and other malformations should be sought during the preoperative evaluation of a patient with congenital hydronephrosis.

Aged↗

[Adriamycin versus ftorafur in the prevention of recurrence of superficial carcinoma of the bladder].

We performed a randomized prospective study in 40 patients with primary superficial carcinoma of the bladder who had been submitted to TUR. These patients were divided into two groups; one received intravesical adriamycin and the other oral ftorafur. We analyzed tumor size, number and grade and determined the recurrence rate (IR), recurrence rate/month (RR) recurrence rate/cystoscopy (RIC), disease-free interval, survival curves, and drug toxicity. After a mean follow-up of 19.7 months for the patient group that received adriamycin and 20.2 months for the group on oral ftorafur, the IR, RR, and RIC for the group on adriamycin were 40, 2.20 and 0.08%, respectively, and 33.3, 1.64 and 0.07% for the patient group on ftorafur (difference: NS). Drug toxicity was practically absent for the group on adriamycin whereas treatment had to be discontinued in two of the patients on ftorafur due to gastric intolerance. Furthermore, ftorafur was shown to cause a transient increase of transaminase levels in 4 patients, cutaneous changes and alterations in fingernails in 1 patient, and intense dermatitis during the last month of treatment in another patient. However, it was not necessary to discontinue treatment.

Carcinoma↗

[Paratesticular rhabdomyosarcoma].

We report a case of paratesticular rhabdomyosarcoma in a 5-year-old boy who was submitted to radical orchidectomy via the inguinal approach and high ligation of the spermatic cord. Clinical and retroperitoneal staging classify this case under group I of the Intergroup Rhabdomyoma Study. Adjuvan chemotherapy with 12 courses of VAC have achieved a good clinical course to date (14 months after surgery) and a good outcome is predicted. We review the literature and discuss the features of this mesenchymal tumor.

Child, Preschool↗

[The immotile cilia syndrome as a cause of sterility].

We investigated the relationship between ciliary dyskinesia--commonly referred to as inmotile cilia syndrome--and sterility. In the past two years, we have accurately diagnosed 6 new cases of a total of 20 suspected as having this condition. To make the diagnosis, complete clinical, radiological, ultrastructural and spermatic work up was performed. All males in the fertile age were found to be sterile with spermatozoides with no motility. Sterility may initially go undetected in these patients due to early intense ORL and respiratory symptoms they present. However, mild forms of this disease entity may be asymptomatic and patients may consult for sterility with a clinical picture of scantily florid chronic bronchitis like that of smokers. Coincidental situs inversus may be useful in making the diagnosis.

Adolescent↗

[Vesicovaginal fistula in an 8-year-old girl].

We report a case of vesicovaginal fistula in an 8-year-old girl caused by a foreign body in the vagina. The foregoing condition was associated with vesical lithiasis. Correction of the fistula was performed during the same surgical procedure for stone removal, without waiting for 3-6 months to elapse as advocated by most of the authors. A review of the literature revealed only one such case has been reported earlier.

Child↗

[Bladder carcinoma in patients under 40 years of age].

A retrospective study was undertaken on 147 cases of bladder tumors T1 GI-II that were treated over the period 1984-1987. Of these, 9 (6.1%) were tumors in patients under 40 years of age. All the foregoing 9 cases, and only 97 of the remaining 138 cases could be evaluated and compared. The male to female ratio was 8:1. Both patient groups were similar with respect to tumor grade, number, and size. All patients were treated by TUR and received chemotherapy post-operatively. Of the 9 patients under 40 years of age, 2 (22.2%) patients classed as GII had tumor recurrence and total cystectomy was performed in one (11.1%) due to tumor upgrading; whereas for the remaining patient group tumor recurrence was 37.7% and tumor progression was 6.6%. This finding shows that the choice of treatment or the decision to follow patients more or less closely cannot be based on patient age. Treatment should be based on patient overall condition and tumor grade and stage.

Adult↗

[Sexually transmitted recurrent urinary infection of the male].

We describe a case of recurrent urinary tract infection in a male patient that had been repeatedly associated with sporadic sexual intercourse with his partner. The timing of the episodes and the bacteriological findings indicate this to be another uncommon case of urinary tract infection sexually transmitted by the female to the male.

Adult↗

[Congenital mesoblastic nephroma in childhood. Our experience apropos of 3 cases].

Congenital mesoblastic nephroma (CMN) is a rare, generally benign renal tumor. A better knowledge of its natural history has changed the therapeutic approach. Currently, aggressive therapy must be exclusively reserved for the sarcomatous forms or Wilms' tumor with sarcomatoid features. The cell variant reported in our series was treated with efficacy by surgery alone. Early recognition of the lesion, preferably prenatally, is warranted in order to perform surgery early or detect hydrops fetalis, a possible complication of pregnancy.

Female↗

[Nephro-urologic manifestations of the acquired immunodeficiency syndrome in our country].

We intend to approach the genitourinary and nephrological pathologies presented in our environment by patients with HIV infection. To this end we have carried out a retrospective study on a series of patients selected on the basis of follow-up possibility. A continuous history, recording a detailed clinical examination including repeated sampling and serological testing, would allow us to stress the relevance of hidden urological pathologies which these patients rarely complain about. Further studies with larger series are required to be able to establish a relationship between nephro-urological symptoms and the disease evolution parameters.

Acquired Immunodeficiency Syndrome↗

[Giant hydronephrosis with an unusual angiographic pattern].

The paper describes an unusual angiographic pattern within the context of stenosis of the pyeloureteral union and giant hydronephrosis of the adult, with a presumed congenital origin. From the embryonic point of view we discuss the remote possibility of this being a real "agenesis" of the renal artery with no agenesis of the kidney, irrigated by multiple segmental arteries following the characteristic metamerism of the mesonephros. On the other hand, it seems more consistent to explain such vascular pattern as an image of severe atrophy, in correlation with the hydronephrosis advanced stage, and not as a primary congenital defect. However, the interaction of both factors (congenital-malformative and acquired-involutive) could be more overlapped than what initially appears to be.

Adult↗

[Endometrioid carcinoma of the prostate: a histogenetic dilemma with therapeutic implications].

An additional case of endometrioid carcinoma of the prostate is presented. We discuss the origin and significance of this controversial and uncommon tumor type. The different histogenic hypotheses that have been put forward not only imply a distinct embryologic conception but also an appropriate therapeutic approach. The good results achieved by antiandrogen therapy in the case reported herein have prompted us to consider this treatment modality as a valid adjunct to surgery.

Aged↗