Biomedical subjects
Publications and source records attributed to M Underhill.
2'-Chloropentostatin (2-CP) is a new nucleoside antibiotic produced by Actinomadura sp. ATCC 39365. A selectively sensitive assay organism, Enterococcus faecalis PD 05045 (MIC 0.005 micrograms/ml) was instrumental in the discovery of this compound. 2-CP is a tight-binding inhibitor of adenosine deaminase (Ki = 1.1 X 10(-10) M).
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An automated thermal desorption gas chromatography technique has been adapted to analyse traces of volatile compounds in proprietary food-wrapping films. Fourteen brands of polyvinylchloride film, seven brands of polyethylene film and one polyvinylidene chloride film were discriminated. Prior infrared analysis was used to identify the polymer type. The chromatograms showed minor changes in volatiles along the length of a roll of film and major changes in films exposed to daylight or in contact with cannabis resin.
A set of experiments tested the idea that an examiner can distinguish glass acquired by backward fragmentation from that acquired by contact with already-broken glass. A window was broken. The exterior surface of the breaker's clothing was brushed and hair-combings taken and these were searched for glass fragments. Wearing the same clothing the breaker then cleared up the broken glass and further hair-combings and brushings of the clothing surface were taken. The size, shape and presence or absence of an original flat surface was recorded for the recovered fragments. The distributions within these parameters were compared for the two methods of acquisition and association between the method and the parameters was tested using contingency tables. It was found that fragment shape does not identify the method of acquisition and that a high proportion of fragments retaining the original outer surface shows that the glass was acquired by backward fragmentation.