New derivatives of 4-aminobenzoic and 4-chlorine-2-hydroxybenzoic acids hydrazides were synthesized by the condensation reaction of these hydrazides with aldehydes and ketones, derivatives containing in their molecule azometine and hydrazone groups. The obtained products are potentially bioactive. The study of their "in vitro" biological activity was performed on some pathogenic germs, both gram-positive and gram-negative. The results show that the tested substances are more active towards the gram-positive germs.

Anti-Bacterial Agents↗

PubMedDate not supplied

Derivatives of asparagic acid with hypotensive action.

To obtain new compounds with biological activity, 1-[N-(p-nitrobenzoyl)-alpha-D,L- asparagyl]-benzimidazole derivatives were synthesized by decyclization of 2-(p-nitrophenyl)-4-[2'- (diethylamino) ethyl-carboxymethyl]-delta 2-oxazolinone-5 with benzimidazole, 2-methylbenzimidazole and 5,6-dimethyl-benzimidazole. The synthesized products show a hypotensive action comparable to that Hipopresol.

Animals↗

PubMedDate not supplied

[The production of nitro esters active at the level of the cardiovascular system].

In order to obtain new compounds with cardiovascular activity, some esters of nitric acid with ethanolamine were synthesised, using some aromatic acids, acexamic acid, the natural methylxanthines-theophylline and theobromine. The melting points, yields and solubility of the new compounds were determined, and the chemical structures were confirmed by elemental analysis C, H, N, and by spectral analysis in KBr.

Cardiovascular Agents↗

PubMedDate not supplied

[The synthesis and biological activity of new disubstituted carbanion ylides from pyridazine].

Continuing the investigations in view obtaining new carbon-nitrogen stable dissiniu-ilydes, were obtained new 3-phenyle-pyridaziniu-ylides carbanion disubstituted. The antimicrobial and antifungus action of the products VIa, VIb, VIIa, VIIb and VIIc also studied.

Anti-Bacterial Agents↗