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M Uram

Publications and source records attributed to M Uram.

25 records · Page 2Linked to original sources
PubMed1982

The cutaneous manifestations of Sturge-Weber syndrome.

The Sturge-Weber syndrome is characterized by the presence of a leptomeningeal hemangioma variably associated with a facial nevus flammeus, seizure disorder, mental retardation, hemiparesis, homonymous hemianopsia, glaucoma, and other signs and symptoms. The relationship between the cutaneous manifestations and the other features of this disorder was studied in 35 patients. We observed that all patients with the facial nevus flammeus had involvement of the upper eye lid or forehead. Bilateral cutaneous involvement was common and when present, was often associated with extensive lesions of the trunk and extremities. The distribution of the cutaneous lesions appeared to be unrelated to that of the trigeminal nerve. A subgroup of patients, the syndrome's "forme fruste," were identified. There appeared to be no relationship between the presence and extent of the cutaneous lesions and the observed seizure disorder, difficulty of seizure control, intellectual deficit, hemiparesis, homonymous hemianopsia, and intracranial calcification. Notably, the "forme fruste" patients appeared to be spared from glaucomatous involvement and from choroidal hemangioma. We will also discuss other aspects of this syndrome.

Adolescent↗
PubMedDate not supplied

Effects of aging on spinal opioid-induced antinociception.

Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive stimuli. Using the tail-flick analgesiometric assay, 25- to 26-month-old rats responded significantly faster to the heat source than 15- to 16-month-old animals, but no significant differences were noted between the 5- to 6-month-old and aged rats. Another series of investigations compared the effects of aging on the spinal antinociceptive properties of the mu opioid agonist [D-Ala2,N-methyl-Phe4,Gly5-ol] enkephalin (DAMPGO) and the delta agonist [D-Pen2,D-Pen5] enkephalin (DPDPE). In these studies, young, mature, and aged rats were injected intrathecally (IT) with different doses of DAMPGO or DPDPE, and opioid-induced antinociception was tested on the tail-flick test. All three age groups responded to IT DAMPGO in a dose-dependent manner but, for the most part, higher spinal doses were required to produce significant elevations in tail-flick latency in the aged cohort of rats. The spinal analgesic effects of DPDPE also declined with advanced age. The aging process apparently alters the pain-inhibitory function of mu and delta opioid receptors in the rat spinal cord.

Aging↗
PubMedDate not supplied

Survey of health care coverage of high school football in southern California.

We surveyed 240 high schools about various aspects of the health care coverage of their football athletes. Approximately 70% of these schools had team physicians, and more than one third of these had more than 1 team physician. Seventy-two percent of high schools had physician coverage for scheduled games. Practices and scrimmages were not covered. Sixty-nine percent of the schools reported having an athletic trainer for home games. Basic equipment was often lacking. Recording and tracking of athletic injuries were inconsistent. An overall team approach for medical coverage was noted. Concern was raised about adequate physician or medical coverage with emphasis on greater input from the school administration, community hospitals, and physicians.

California↗
PubMedDate not supplied

Combined phacoemulsification, endoscopic ciliary process photocoagulation, and intraocular lens implantation in glaucoma management.

The safety and efficacy of combined cataract extraction and intraocular lens (IOL) implantation with endoscopic ciliary process photocoagulation in glaucoma management was evaluated. Ten patients with uncontrolled open-angle glaucoma and cataract prospectively underwent concomitant phacoemulsification, endoscopic ciliary process photocoagulation, and posterior chamber IOL implantation. With a mean follow up of 19.2 months, the mean intraocular pressure (IOP) decreased from 31.4 mm Hg preoperatively to 13.5 mm Hg postoperatively, an absolute decrease of 57%. This represented a significant decrease for each of the patients. The visual acuity of each also improved. Transient vitreous hemorrhage developed in one patient, but no cystoid macular edema or any other significant complications occurred and all eyes were quiet. There were no lens implant dislocations. There was no progressive visual field loss at 1 month post surgery, but such loss was noted in one patient 1 year after treatment. Good IOP control on no medical therapy was attained in one half of the patients. It may be concluded that this combined procedure provided effective management of cataract and glaucoma with a minimum of postoperative care. The safety and efficacy of this approach as compared with cataract surgery combined with filtration remains to be determined.

Cataract↗