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M Urso

Publications and source records attributed to M Urso.

6 recordsLinked to original sources
PubMed1990

Renal function during calcitriol therapy in chronic renal failure.

Some authors have reported that vitamin D treatment worsens renal function. We studied 10 patients with stable renal function, who were given calcitriol (0.5 micrograms/day) for a 4-month period. Creatinine and inulin clearance were performed at the beginning and at the end of the treatment. Although serum creatinine increased and creatinine clearance decreased, inulin clearance did not show significant variations. Furthermore, serum creatinine fell to the baseline value within 60 days after discontinuation of vitamin D therapy. The increased serum creatinine may be explained by an augmented release from muscular tissue, probably due to the improvement of uremic myopathy induced by calcitriol.

Adult↗
PubMed1986

Biofiltration vs. bicarbonate dialysis: influence on plasma volume changes and extravascular fluid mobilization.

The present study compares the effects of bicarbonate hemodialysis (Bic. HD) and biofiltration (BF), a new hemodiafiltration technique, on plasma volume (PV) changes and extravascular fluid mobilization (Vfm). Ten uremic patients underwent one experimental session of Bic. HD and, one week later, one of BF, both on the second dialysis of the week. Net ultrafiltration rate was limited to 700 ml/min. At the start of each session, whole blood volume (WBV), PV and red cell volume (RCV) were determined using 5 mu Ci of radioiodinated serum albumin (RISA). PV and Vfm were calculated at hourly intervals using a serial hematocrit method. On Bic. HD, PV increased at 60 min. then decreased at 120 and 180 min., with efficient Vfm only during the first hour. On BF, PV increased throughout treatment, with greater Vfm. It would appear that PV is better preserved in BF, on account of more efficient Vfm.

Acetates↗
PubMedDate not supplied

Uremic myopathy and calcitriol therapy in CAPD patients.

During 7 months of calcitriol treatment in eight CAPD patients, significant increases in serum creatinine and daily excretion of this substance in dialysis fluid were observed, but there was a significant decrease in creatinine in the urinary daily output. When therapy was stopped, creatinine levels fell to baseline in serum and peritoneal fluid, and urine values continued to decrease as previously observed. Dynamometric performance showed a significant increase during treatment, which remained after drug withdrawal. These findings suggest that the transient increase of serum creatinine during calcitriol treatment may be a result of an increased production and release of this metabolite from muscle.

Aged↗