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Biomedical subjects

M Usandizaga

Publications and source records attributed to M Usandizaga.

At least 19 recordsLinked to original sources

Intradermal and intramuscular route for vaccination against hepatitis B.

A recombinant hepatitis B vaccine was administered to high-risk hospital personnel by intramuscular (20 micrograms) or intradermal (2 micrograms) injections for the primary immunization (n = 69) with three doses and booster immunization (n = 51) with one dose. Basic vaccination performed intramuscularly gave rise to significantly higher seroconversion levels (97.2% versus 78.1%) and geometric mean titres of antibody (1649 versus 126 IUl-1) as compared with the intradermal route. Intradermal administration did not boost antibody titres in patients previously vaccinated intradermally. Adverse reactions were not serious or severe. The intramuscular route is recommended as the procedure of choice when vaccinating against hepatitis B.

Adult↗

[Tobacco and pregnancy. Weight of the newborn infant and weight gain of the mother].

865 patients delivered at women's clinic "La Paz" have been examined, to prove the hypothesis, that the weight of the newborn may be influenced by smoking indirectly via nutrition. 276 of the 865 women did smoke. In this group the weight of the newborns was lower significantly. If we select both groups of smoking and nonsmoking patients appropriate to the weight increase during pregnancy above or below the average value, we can state that those fetuses had a intrauterine growth retardation whose mothers did smoke and had a lower weight increase than the average value of all pregnant women.

Birth Weight↗

[Definition of intrauterine growth retardation].

In order to answer the question as to the limit of intrauterine foetal growth retardation, we compared three weight values at birth: two standard deviations below the mean, namely the fifth and tenth percentiles. The comparisons were made on the intrapartum and early neonatal mortality rates of 19,256 infants born during 1980 in "La Paz" Maternity Hospital of Madrid. Our results show that we have to consider as newborn with a growth retardation those infants whose weight at birth is lower than the fifth percentile for their gestational age and sex. In this group of infants, the intrapartum and early neonatal mortality rates are significantly higher than among newborn with a superior weight. At the same time, we found that the mortality among newborn with a weight between the fifth and tenth percentile was not significantly higher than that observed among infants with a weight at birth greater than the tenth percentile.

Birth Weight↗