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Biomedical subjects

M V Braimbridge

Publications and source records attributed to M V Braimbridge.

144 records · Page 8Linked to original sources
PubMed1969

Triple Starr valve replacement.

Of nine patients who have had triple valve replacements for organic rheumatic triple valve disease two died in the postoperative period from inadequate myocardial reserve, and a third died four months later from cerebral embolism originating from clot on the left atrial wall. The remainder are well and, except for one, leading normal lives. Though cardiac transplantation has been recommended and used successfully for triple valve disease by Cooley, it is suggested that the long-term outlook today of triple valve replacement is likely to be better than that of transplantation.

Adult↗
PubMedDate not supplied

Evaluation of perfusion conditions in cardiopulmonary bypass.

Fresh sections of left ventricular drill biopsies, taken at the beginning and end of cardiopulmonary bypass in 164 patients undergoing aortic valve replacement, have been analyzed for myocardial function. This has been assessed by changes in biochemical function, measured by semi-quantitative histochemical methods, and by changes in birefringence, measured quantitatively by polarization microscopy. It has been shown that continuous perfusion at 32 degrees C with the heart beating provided better preservation than did the other three perfusion procedures, in all of which the heart was fibrillating. More recently, in a small number of cases, cardioplegic arrest has been found to given even better preservation.

Aortic Valve↗
PubMedDate not supplied

'Early' ischemia and reperfusion-induced arrhythmias: antiarrhythmic effects of diltiazem in the conscious rat.

The ability of diltiazem to prevent early ischemia and reperfusion-induced arrhythmias was investigated in conscious rats with coronary artery occlusion. During a 30-min period of occlusion of the left coronary artery, 100% of placebo-treated animals exhibited ventricular tachycardia, 65% exhibited ventricular fibrillation and the mean total number of premature ventricular complexes was 1076 +/- 254. Diltiazem (0.5 or 2.0 mg/kg body weight, given intravenously 10 mins prior to coronary occlusion), reduced the incidence of ventricular tachycardia to 62% (P less than 0.01) and 54% (P less than 0.001), respectively and the incidence of ventricular fibrillation to 31% (P = NS) and 15% (P less than 0.01), respectively. The total number of premature ventricular complexes was also reduced to 248 +/- 78 (P = NS) and 156 +/- 55 (P less than 0.02). The development of ST segment elevation, induced by coronary artery occlusion, was delayed in both drug-treated groups. Similarly, diltiazem, at the same doses, reduced the incidence of ventricular fibrillation induced by reperfusion after 5 mins of coronary artery occlusion from 100% to 50% (P less than 0.01) and 25% (P less than 0.001) and mortality from 87% to 42% (P less than 0.02) and 25% (P less than 0.01), respectively. The anti-arrhythmic effects of diltiazem were not related to changes in heart rate and all groups showed similar occluded zone sizes, as measured by a fluorescent microsphere technique. Thus, diltiazem affords substantial protection against both early ischemia-induced ventricular arrhythmias and reperfusion-induced arrhythmias and this action may be associated with the beneficial effects on ischemia-induced ST segment elevation.

Animals↗
PubMedDate not supplied

Assessment of the heart by histochemical and birefringence techniques as compared with ventricular function tests.

We have compared results of isovolumic ventricular function studies and results of histochemical and birefringence examinations of biopsy specimens from 80 isolated canine hearts both before and after three hours of preservation utilizing several variables. The direct and derived mechanical tests and histochemical and birefringence assessments of the myocardium were correlated by multiple regression analysis. Our results suggest that initial ventricular health may be indicated by acid hematein staining of free phospholipids and by the response of myocardial birefringence to adenosine triphosphate and calcium, while succinic dehydrogenase staining and birefringence without adenosine-triphosphate treatment are more useful in showing ventricular deterioration during operation.

Animals↗