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Biomedical subjects

M V Dorfman

Publications and source records attributed to M V Dorfman.

At least 19 recordsLinked to original sources
PubMed1991

[The separate determination of pulmonary vital capacity by spirography in combination with zonal rheopneumography].

The authors purpose and describe a method for separate determination of vital lung capacitance for each lung based on zonal rheopneumography and general spirography. Comparison of data obtained by this method as compared with results of radioisotope examination of the lungs revealed a high degree of correlation between them. The method was used in 5000 patients and proved highly effective.

Evaluation Studies as Topic↗
PubMed1990

[Questionnaire-based determination of groups at high risk for lung cancer].

The factor analysis of qualitative parameters carried out in 968 patients with lung cancer helped identify certain features which may play the key role in the development and, consequently, diagnosis of various types of the disease. In workers of major industries, smoking proved a significant factor of higher incidence of lung cancer. Formation of the habit at an earlier age, its intensity and concomitant occupational hazards were found to increase the risk of cancer, particularly, in males. Mass screenings and questionnaire--based interviewing of smokers are suggested. Young age and heavy smokers should be included in groups at risk irrespective of occupation.

Age Factors↗
PubMed1987

[Active specific immunotherapy in patients with lung cancer following tumor removal].

Total levels of lymphocytes, T-lymphocytes as well as concentrations of their theophylline-sensitive and theophylline-resistant fractions were measured in 63 lung cancer patients, 5 cases of benign pulmonary tumors and 16 healthy controls. A significant decrease in T-lymphocyte and theophylline-resistant lymphocyte levels was registered in lung cancer patients. Forty-six radically-operated patients received 3 subcutaneous injections of an autologous tumor cell vaccine. The procedure was free of complications. It was followed by an improvement in cell-mediated immunity and produced a higher 2-year survival rate.

Adenocarcinoma↗
PubMed1985

[Interaction of the tumor and immunocompetent cells of lung cancer patients in diffusion chambers].

Peculiarities of interaction of tumour cells and lymphocytes were studied in cultivating explants of 19 human lung tumours in diffusion chambers. Results were analyzed with due regard for the histological structure of tumours, level of tissue differentiation and clinical stage of the disease. Criteria are developed for evaluating the interaction of tumour cells and lymphocytes, namely: the relative content of lymphocytes in culture, the number of spheroids and a way of their destruction (edge one or with lymphocytes), presence of lymphocytic clusters and aggregates of blast-like cells, presence of tumour cell-lymphocyte complexes. The obtained results may be used for estimation of the tumour malignancy degree.

Adenocarcinoma↗
PubMed1983

Three-year results of surgical and combined treatment of lung cancer with a preoperative radiotherapy.

In this paper the analysis of immediate results of clinical material is given which has been accumulated by participants of the joint investigation in some CMEA member countries (Project 3-9.1.1 of the Lung Cancer Program; Bulgaria, Hungary, Poland, USSR, Czechoslovakia) with the aim to study the effectiveness of one of the variants of combined treatment of patients with differentiated forms of lung cancer. Combined treatment received 286 patients, 231 patients (control group) were treated surgically. It is concluded that the preoperative radiotherapy using the method of the intense concentrated course does not complicate the operation itself and is not reflected in the nature and frequencies of intraoperative complications. However, in combination with the subsequent surgical intervention, it significantly elevates the number of postoperative complications, particularly of those of purulent nature (bronchial fistula, intrapleural empyema) and also the lethality. The difference between the groups in this respect is particularly significant at State III of the disease. Late results were studied in 379 patients (in 221 of them after a combined treatment and in 158 after surgical treatment). For more than 1, 3 and 5 years survived 76.5, 49.4 and 34.48% (combined treatment) and 77.2, 41.2 and 20.7% (surgery), respectively. The differences between the groups in favor of the combined treatment are due to patients with Stage III planocellular carcinoma.

Combined Modality Therapy↗