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Biomedical subjects

M V Griffiths

Publications and source records attributed to M V Griffiths.

23 records · Page 2Linked to original sources
PubMed1977

Effect of a new antithrombotic agent at microvenous anastomotic sites.

In the search for a suitable agent to prevent thrombosis at microvenous anastomotic sites, a double-blind sequential trial was performed to evaluate the effect of a new potent antithrombotic agent, 6-methyl-1,2,3,5-tetrahydroimidazo [2, 1-b] quinazolin-2-one hydrochloride monohydrate (BL3459). Rabbit neck veins 1.5 mm in diameter, were chosen for study and were anastomosed with Nakayama ring pins. In a comparison with heparin, the results show a highly statistical diminution in thrombosis rates when using BL3459. It would appear that this new compound would substantially improve tissue survival if it were adopted for use clinically for grafting autologous tissue that is based on an anastomosed microvascular pedicle. It could also prove to be clinically useful to treat a variety of problems requiring an antithrombotic agent.

Animals↗
PubMed1976

An implantable electromagnetic sound source for speech production.

Many operative and nonsurgical procedures have been designed for vocal rehabilitation following laryngectomy, but as yet a consistently successful solution with a negligible complication rate has failed to materialize. In our laboratory during the last two years, experiments have been carried out in dogs using active electromagnetic devices placed in the retropharynx as an energy source for speech production. An implantable porous coated stainless steel electromagnetic device energized from an externally controlled oscillator has been developed. Factors under investigation included biocompatibility of materials, durability, noise quality and intensity, together with the efficiency of the system. As a result of the favorable findings, it is envisaged that this system will soon be used in a carefully designed restricted clinical trial as a secondary procedure in those consenting cured laryngeal cancer patients who have failed to develop esophageal speech.

Animals↗