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M V Jones

Publications and source records attributed to M V Jones.

47 records · Page 3Linked to original sources
PubMed1988

Central origin of vagal nerve fibres innervating the fundus and corpus of the stomach in rat.

The origin of vagal nerve fibres innervating the anterior and posterior walls of the fundus and corpus of the rat stomach was investigated using the axon tracing dye, Fast blue. The secretomotor nerve supply to the rat stomach was predominantly ipsilateral. A large majority (98-99%) of the vagal perikarya innervating the anterior fundus and corpus were located on the left side of the brainstem. A large majority (96-99%) of the vagal perikarya innervating the posterior fundus and corpus were located on the right side. Vagal perikarya were arranged in longitudinal, dorsal cell columns which extended beyond the normally accepted cytoarchitectural limits of the dorsal motor nucleus of the vagus (DMV). A few vagal cells innervating the fundus were also found in the nucleus ambiguus. Vagal cell columns innervating the anterior and posterior fundus extended rostrocaudally over a distance of up to 4 mm and projected caudally as far as the cervical spinal cord. Vagal cell columns innervating the anterior and posterior corpus were more compact, extended over a distance of 2-3 mm, and projected rostrally as far as the inferior salivatory nucleus of the glossopharyngeal nerves. Vagal cell columns for the fundus and corpus overlapped in the region of the DMV which lay immediately ventral to the area postrema. Between one-third to one-half of the vagal cells innervating the fundus and corpus were concentrated under the area postrema. A simple form of viscerotopic organisation appears to occur within the vagal cell columns innervating the fundus and corpus.

Animals↗
PubMed1986

The use of alcoholic paper wipes for routine hand cleansing: results of trials in two hospitals.

The use of alcoholic paper hand wipes by nursing staff was assessed in two trials. No significant changes in total viable counts from finger imprint samples were observed when wipes were used, but some decrease in samples positive for Enterobacteriaceae and Staphylococcus aureus was recorded. The wipes were found to be pleasant and convenient to use. It is concluded that wipes are an acceptable alternative to soap and water for routine hand cleansing.

Bacteria↗
PubMed1985

Thermostability of enzymes of the tricarboxylic acid cycle of Bacillus coagulans.

The thermostability of four enzymes of the tricarboxylic acid cycle has been studied in the facultative thermophile, Bacillus coagulans. Although isocitrate dehydrogenase appeared to be more temperature-sensitive in whole-cell extracts of cultures grown at 30 degrees C compared with that in cultures grown at 55 degrees C, this difference could be largely eliminated by the removal of cell-wall material. The specific activity of each of the enzymes examined was approximately threefold higher in cultures grown at 55 degrees C than in those grown at 30 degrees C. The maximum temperature, Arrhenius plot and effect of stabilizing agents for each enzyme were examined and found to be independent of growth temperature. Sodium chloride (10% w/v) was an effective protective agent for fumarase, aconitase and malate dehydrogenase. Protection from thermal denaturation of isocitrate dehydrogenase, aconitase and fumarase but not malate dehydrogenase was also given when the enzymes were heated in the presence of their substrates. These results are discussed in light of the generalized theories of facultative thermophily which have been proposed.

Aconitate Hydratase↗
PubMed1979

Regional cerebral blood flow changes during severe fetal asphyxia produced by slow partial umbilical cord compression.

We studied the effects of severe partial asphyxia on regional cerebral blood flow and arterial blood pressure in the unanesthetized, physiologically stable fetal lamb. Cerebral blood flow was measured by the microsphere technique before and during partial umbilical cord compression. Asphyxia sufficient to decrease pH from 7.40 to 7.04 and reduce oxygen saturation from 50% to 19% increased cerebral blood flow to all areas of the brain with the largest increases going to the brain stem (275% of control) and deep cerebral structures (240% of control). Fetal arterial blood pressures increased from a mean of 58 mm Hg to a mean of 71 mm. Hg during asphyxia. The blood pressure increases correlated closely with the regional cerebral blood flow increases. There was a poor correlation between cerebral blood flow increases and changes in Paco2' pH, or oxygen saturation. We conclude that during severe fetal asphyxia arterial blood pressure is the critical factor in determining cerebral blood flow.

Acidosis↗
PubMed1975

Physiological role for the membrane bound ascorbate-TMPD oxidase in pseudomonas putida.

The activity of the membrane-bound ascorbate-TMPD oxidase in Pseudomonas putida varies with growth conditions and age of the culture. A comparison of the effects of cyanide and azide on the oxidation of various substrates suggests that ascorbate-TMPD oxidase is not the terminal oxidase for NADH or succinate oxidation. However, it does have a role in the oxidation of nicotinate, and may act as an additional terminal oxidase under certain other growth conditions.

Ascorbate Oxidase↗
PubMed1972

The oxidation of nicotinic acid by Pseudomonas ovalis Chester. The terminal oxidase.

In cell-free extracts of Pseudomonas ovalis nicotinic acid oxidase is confined to the wallmembrane fraction. It is associated with an electron-transport chain comprising b- and c-type cytochromes only, differing proportions of which are reduced by nicotinate and NADH. CO difference-spectra show two CO-binding pigments, cytochrome o (absorption maximum at 417nm) and another component absorbing maximally at 425nm. Cytochrome o is not reduced by NADH or by succinate but is by nicotinate, which can also reduce the ;425' CO-binding pigment. The effects of inhibitors of terminal oxidation support the idea of two terminal oxidases and a scheme involving the ;425' CO-binding pigment and the other components of the electron-transport chain is proposed.

Azides↗