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Biomedical subjects

M V Khomenko

Publications and source records attributed to M V Khomenko.

At least 19 recordsLinked to original sources
PubMed1994

[The prognosis of the nature of the course and outcome of infectious endocarditis].

Prognostic significance of various clinical and laboratory indices for predicting the course and outcome of infectious endocarditis (IE) has been analyzed for 139 IE patients aged 15-68 (77 males and 62 females). The unfavourable prognosis was associated with uncontrollable sepsis, persistence of circulating immune complexes and developing glomerulonephritis. The latter had also prognostic signs unfavourable for IE: moderate or severe proteinuria and/or cylindruria, reduced renal function, diffuse proliferation, pronounced extracapillary and/or tubulointerstitial components.

Adolescent↗
PubMed1993

[The characteristics of cylindruria in patients with chronic glomerulonephritis].

Qualitative and quantitative indices of cylindruria were studied in 325 patients aged from 15 to 64 with various morphological forms of chronic glomerulonephritis (CGN). In 237 of them function of kidneys was unchanged while remaining 88 patients revealed various degrees of chronic renal failure (CRF). Parameters of cylindruria in patients with CGN varied widely, significant correlation having been established between presence of erythrocytic cylinders in urinary residue and degree of haematuria. Large granular cylinders were observed in patients with severe and moderate CRF as distinct from patients with normal renal function and initial stage of renal insufficiency.

Adolescent↗
PubMed1992

[The characteristics of hematuria in chronic glomerulonephritis and nonglomerular diseases of the kidneys and urinary tract].

Upon the analysis of qualitative and quantitative characteristics of hematuria in renal and urinary tract affections it was established that whatever the red blood cell count in the urine, hematuria is primarily glomerular in contrast to nonglomerular in chronic glomerulonephritis and nonglomerular diseases of the kidneys and urinary tracts, respectively. Morphologic studies of urinary red blood cells using phase-contrast microscopy proved a valuable tool for identification of hematuria origin.

Chronic Disease↗
PubMed1991

[Systemic lupus erythematosus and pregnancy: specific features of gestation and course of the disease].

The authors analyze the course and outcomes of 33 pregnancies in 26 women suffering from systemic lupus erythematosus (SLE). In patients with active SLE the incidence of gestoses and abnormalities of the newborns is significantly higher than in those with inactive SLE, whose gestational and neonatal complication rate is almost the same as in healthy women. Pregnancy course and outcomes are particularly unfavorable in cases with lupus glomerulonephritis.

Abortion, Spontaneous↗
PubMed1991

[The beta 2-microglobulin content of the blood serum and urine in patients with primary chronic and lupus glomerulonephritis].

The authors studied the content of beta 2-microglobulin (beta 2-MG) in the blood serum and its excretion with the urine in 85 patients with chronic and 35 with lupoid glomerulonephritis (CGN and LGN) depending on the activity of the disease and state of the renal function. In active CGN and LGN one could observe a distinct increase of the content of beta 2-MG in the blood serum and an increase of its excretion with the urine that may be related to presence of marked dystrophic changes of the canalicular apparatus of the kidneys leading to disorders of reabsorption and beta 2-MG catabolism as well as disorders of the immune homeostasis revealed in these diseases. Results indicate that the beta 2-MG levels in the blood serum and urine may be considered as criteria of CGN and LGN activity.

Adolescent↗
PubMed1991

[Significance of the studies of urinary syndrome in clinical practice].

The study of urinary sediment is essential in laboratory diagnosis. Conventional clinical methods are now used in line with computer-aided techniques and additional microscopy of the sediment elements. The paper provides a brief analysis of clinical situations characterized by appearance in the urine of abnormal numbers of leukocytes, erythrocytes, casts; provides clinical assessment of additional microscopic methods able to accentuate qualitative characteristics of the urinary syndrome; considers possibilities of application of the urinary sediment data in follow-up to improve diagnosis and control on-going treatment.

Adult↗
PubMed1991

[Birefringent fat bodies in the urine of patients with primary and secondary glomerulonephritis].

Results are presented of an investigation of birefracting fatty bodies in the urine of patients with primary chronic lupoid and Henoch glomerulonephritis. There was a close correlation between the presence of birefracting fatty bodies and severity of glomerulonephritis independent of the morphological picture of the disease and state of renal function. Reduction of the activity of the disease in the course of pathogenetic treatment characterized by a decrease or disappearance of proteinuria was accompanied by a distinct reduction of the level of birefracting fatty bodies or their disappearance.

Birefringence↗
PubMed1991

[Minimal change glomerulonephritis in adults].

Glomerulonephritis with minimal alterations presents one of the most complex problems of nephrology. The authors provide the data on the disease incidence and clinico-laboratory correlations in 33 adult patients, discuss problems of the treatment policy.

Adolescent↗
PubMed1990

[The effect of pregnancy on the course of different clinical forms and morphological variants of primary chronic glomerulonephritis].

The author relates the data on the time-course of changes in diurnal proteinuria, diastolic arterial pressure and blood creatinine in 123 patients with primary chronic glomerulonephritis seen during 159 pregnancies. The dependence of the character of those changes on the respective parameters before conception was analyzed as was such a dependence, in part of the patients, on the morphological disease pattern. The rise of proteinuria and diastolic arterial pressure during gestation was seen more often in women with initial diurnal protein losses exceeding 1g and with arterial hypertension that occurred before pregnancy. The rise of blood creatinine before conception was a prognostically unfavourable sign. Mesangiocapillary glomerulonephritis occurring in the gestation period is viewed as less favourable as compared to mesangioproliferative glomerulonephritis.

Abortion, Legal↗