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M V Korsakov

Publications and source records attributed to M V Korsakov.

10 recordsLinked to original sources
PubMed2000

[Chemobiokinetics of sarcolysin and its peptides with glutaminic acid].

A 14C study of chemobiokinetics of sarcolysin and its peptides of glutaminic acid, dosage and routes of administration was conducted in intact rats and those bearing Walker's carcinoma. Similar in shape for peptides, kinetic curves differed from those found for sarcolysin. The rates of absorption and excretion of sarcolysin peptides in intraperitoneal and, particularly, oral administration were lower than those of sarcolysin. Tumor appeared to play a role in a higher rate of peptide excretion. While sarcolysin and its peptides distribution in organs and tissues was generally identical, time of peak radioactive concentration build-up was different. Time needed for accumulation and excretion of peptides from tumor was much longer than from other organs or tissues. Sarcolysin went chiefly to urine while peptides--to faeces.

Administration, Oral↗
PubMed1989

Methylation of thymine and uracil with free methyl cations formed due to beta-decay of tritiated methane: possible implication in mutagenesis and carcinogenesis.

Exposure of solid thymine and uracil at room temperature to free methyl cations, produced due to beta-decay of tritiated methane, resulted in formation of their 1-, O2-, 3-, O4-, and 6-methyl derivatives. In addition, uracil formed a 5-methyl derivative (thymine); tritium-containing thymine and uracil were also detected. Both thymine and uracil formed predominantly unidentified products which resulted presumably from their oligomerization. Incubation at -195 degrees C did not markedly change the pattern of reaction products. Aqueous-ammonia solutions of these pyrimidines formed methylated derivatives and considerable amounts of methanol and tritiated water. The possible implication of these reactions in mutagenic and carcinogenic effects of tritium-substituted hydrocarbons is discussed.

Alkylating Agents↗
PubMed1986

[Effect of dioxadet on tumors transplanted to the brain].

A newly-developed antitumor drug Dioxadet is capable of passing the blood-brain barrier. The specific activity of rat brain tissue ranged 8-55% of that of blood at different periods after intraperitoneal injection of 14C-labelled Dioxadet. Dioxadet treatment of mice and rats bearing intracranially-transplanted L1210 leukemia and glioma 35 was followed by a 38-48 and 29% increase in survival, respectively.

Animals↗
PubMed1986

[DNA alkylation and repair in female rats subjected to methylnitrosourea exposure at different ages].

Three- and fourteen-month old female rats received a single intravenous injection of 50 mg/kg 14C-methylnitrosourea. Peculiarities of DNA purines alkylation and repair in different organs were studied. The difference in initial methylpurine levels between the two groups appeared insignificant and did not correlate with the rate of tumor frequency registered in chronic experiments using the same mode of treatment. In young animals, the rate of O6-methylguanine repair in all tissues tested equaled or exceeded that in older ones. It is inferred that the rate and site of tumor development are influenced by alkylation level and rates of repair and proliferation in target tissues during treatment.

Aging↗
PubMed1983

Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-N-nitrosourea.

Formation and loss of methylated purines in DNA of various fetal and maternal tissues were measured up to 7 days following intravenous administration of N-[14C]methyl-N-nitrosourea to rats on the 21st day of gestation. Methylation products were detected in all tissues examined, the level in maternal liver being higher than in other tissues. The concentrations of 7-methylguanine and 3-methyladenine decreased faster in fetal than in corresponding maternal tissues, due to a higher rate of DNA synthesis in fetal tissues, as determined by incorporation of labelled thymidine. Removal of the promutagenic DNA lesion O6-methylguanine was most efficient in maternal and fetal liver; but it was very poorly repaired in kidney and brain. The persistence of O6-methylguanine relative to 7-methylguanine was highest in the DNA of fetal brain. The principal targets for the transplacental carcinogenic effect of N-methyl-N-nitrosourea under these experimental conditions were fetal neurogenic tissue and kidney; and malignant tumors developed at these sites in 31-34% and 15-16% of male and female descendants, respectively. These results support the concept that a complex interaction between DNA alkylation, repair and replication is the molecular basis of initiation of carcinogenesis by alkylating agents.

Adenine↗
PubMed1983

[Blood concentration of halothane and its effect on catecholamine levels and hemodynamics in cancer patients during surgery].

The investigation of 22 patients has established the concentration of fluothane in the blood to influence the catecholamine content and the cardio-vascular system. Its increased concentration in the blood results in certain decrease of the level of general catecholamines in the blood, decreased value of systolic arterial pressure and increased frequency of cardiac contractions.

Anesthesia, Endotracheal↗