Biological relevance of gamma-ray-induced alkali-labile sites in single-stranded Dna in aqueous solutions.
Gamma-irradiation in single-stranded phiX174 DNA in aqueous solution in the presence of oxygen produces at least two types of alkali-labile site. One is lethal and gives rise to single-strand breaks by treatment with alkali. The other is non-lethal, but is converted to lethal damage by alkali. The effect of alkali is dependent on temperature. This dependence is different for both types of alkali-labile site.
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