Biomedical subjects

M V Machado

Publications and source records attributed to M V Machado.

3 recordsLinked to original sources

PubMed1988

Atrioventricular septal defect in prenatal life.

In a series of more than 3500 pregnancies referred for fetal echocardiography, 29 cases of atrioventricular septal defect were detected in the fetus. There was a chromosomal anomaly in 14 of these cases, left atrial isomerism in 12, and right atrial isomerism in two. Complete heart block was found in 11 of the cases with left atrial isomerism. Many associated cardiac abnormalities were found, particularly in the fetuses with atrial isomerism; the most common were double outlet right ventricle or aortic arch anomalies. The prognosis was poor in all patients with atrioventricular septal defect detected prenatally. Fifteen pregnancies went to term but there are only four survivors. Two of those have trisomy 21, a further patient has inoperable defects, and only one remains well and is awaiting corrective surgery for a partial atrioventricular septal defect.

Abnormalities, Multiple↗

PubMed1988

Fetal complete heart block.

In a series of over 6000 patients referred for fetal echocardiography during an eight year period, 37 fetuses were found to have complete heart block. There were 16 cases of isolated heart block and 21 cases associated with structural heart disease. All mothers of fetuses with isolated complete heart block had evidence of circulating syndrome Sjögren A antibody (Ro). Only one mother had clinical evidence of connective tissue disease. In the 21 cases associated with structural heart disease there were 17 cases of atrioventricular septal defect, one case of secundum atrial and perimembranous ventricular septal defects, two cases of tetralogy of Fallot, and one case of pulmonary stenosis. All fetuses with atrioventricular septal defects and complete heart block had left atrial isomerism. Additional abnormalities of the great arteries were often found in this group; these were double outlet right ventricle, transposition of the great arteries, pulmonary atresia, coarctation of aorta, and stenosis of the pulmonary or aortic valves. Intrauterine congestive heart failure was a feature of four cases in the group with isolated complete heart block and 11 cases of the group with associated structural heart disease. The outcome in the fetuses with isolated complete heart block was better than in those with heart disease: 12 of the 16 fetuses are alive, two of them have a pacemaker. But only three of the group of 21 fetuses with cardiac malformation are alive, and two of them have a pacemaker.

Echocardiography↗

PubMed1987

Acceleration time in the aorta and pulmonary artery measured by Doppler echocardiography in the midtrimester normal human fetus.

The time to peak velocity was measured by Doppler echocardiography in the pulmonary artery in 102 normal human fetuses (gestational age 16-30 weeks). Time to peak velocity in the aorta was measured in 72. In 58 both measurements could be made in the same fetus. The time to peak velocity was shorter in the pulmonary artery than in the aorta. This difference was statistically significant. This suggests that in the midtrimester fetus mean pressure in the pulmonary artery is higher than in the aorta.

Aorta↗