Biomedical subjects

M V Orlov

Publications and source records attributed to M V Orlov.

21 records · Page 2Linked to original sources

PubMed1984

[Characteristics of the echocardiographic changes in patients with myocardial infarction complicated by heart rupture].

Echocardiographic examination was conducted in 40 patients with acute myocardial infarction, in five cases the course of myocardial infarction was complicated by cardiorhexis. The echocardiograms of patients who died of cardiorrhexis showed marked hyperkinesia in the area of the posterior wall of the left ventricle (in 3 of the 4 cases of anterior myocardial infarction). In the control group compensatory hyperkinesia in the area of the posterior wall of the left ventricle was detected only in 21% of the patients. Moreover, the echocardiograms of those patients who died of cardiorrhexis showed dys- and akinesia in the focus of the affection, 80% of these patients exhibited an enlargement of the right ventricle as compared to 40% of the controls. The parameters of the central hemodynamics in the patients with hyperkinesia who died of cardiorrhexis indicated compensation of the cardiac activity although all patients had marked zones of dys- and akinesia. In the control group they were significantly reduced and pointed to impaired myocardial contractility.

Aged↗

PubMedDate not supplied

[Molecular dynamics of oligopeptides. 1. The use of long trajectory and high temperature data for determination of statistical weight of conformational substates].

The method of molecular dynamics investigations of the particularities of macromolecule physical-chemical properties is discussed. The results, obtained from the calculations of modified dipeptides in different regimes (different temperatures, length of trajectories and ways of thermostat simulation) are compared. The optimal conditions for this peptides calculations are determined: collisional dynamics regime, trajectories not less than 5000 ps, temperature about 1000 K. In this case the figurative point is able to scan the molecule configuration space and the statistically reliable results could be obtained.

Dipeptides↗

PubMedDate not supplied

[Molecular dynamics of oligopeptides. 2. Dynamic correlation functions of the conformational modes of the modified dipeptides].

The method of investigation of dynamic correlation functions in molecules with conformational mobility on an example of modified dypeptides by molecular dynamics is proposed. Comparison of results for different types torsion angles and internuclear distances are carried out. Connection between the chemical structure of peptides and the peculiarities of internal dynamic correlations is established. A question about dynamic isomorphism of amino acids is discussed.

Dipeptides↗