Biomedical subjects

M V Ostrovskiĭ

Publications and source records attributed to M V Ostrovskiĭ.

4 recordsLinked to original sources

PubMed1978

[Components of a native solution that displace the equilibrium distribution of oleandomycin during extraction].

A marked decrease in the coefficient of oleandomycin distribution in the system of the fermentation broth filtrate-butyl acetate was observed during the transfer from the 1st to the following extraction stages. It was supposed that the oleandomycin fermentation broth filtrate contained admixtures affecting significantly the antibiotic distribution between the aqueous phase and organic solvent.

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PubMed1978

[Increase in the oleandomycin distribution coefficient at the extraction stage by using electron carrier-acceptors].

A possibility of increasing the distribution coefficient of oleandomycin on its extraction from the aqueous solution into the organic phase containing an electron carrier-acceptor was shown. It was found that the level of the oleandomycin equilibrium shift into the organic phase depended on the carrier nature, i. e. the donor-acceptor interaction of the carrier and the antibiotic. It was shown that the oleandomycin fermentation broth contained non-identified admixtures, the interaction of which with the antibiotic was higher than its interaction with the acceptor-carriers tested.

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PubMed1977

[Ways to optimize the technological process of oleandomycin reextraction].

Dependence of the oleandomycin distribution coefficient on pH of the acqueous phase and temperature in the system of butylacetate extract-water acidified with orthophosphoric acid was studied. With a purpose of intensification of the process of oleandomycin reextraction, decreasing the antibiotic inactivation and evaporation of the organic solvent it was proposed to perfom oleandomycin extraction at pH 4.0--5.0 accompanied by simultaneous decreasing of the temperature.

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PubMed1977

[Study of the equilibrium conditions for the extractive purification of oleandomycin].

Dependence of the oleandomycin distribution coefficient on the antibiotic concentration, duration of the filtrate storage, extraction temperature and salting-out agents was studied. The distribution coefficient of oleandomycin in the system of fermentation broth filtrate--butylacetate was much lower (about 3 times) than that in the system of oleandomycin phosphate aqueous solution--butylacetate. Addition of sodium sulfate to the aqueous phase provided a significant increase in the oleandomycin distribution coefficient.

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