[Interferon system and proinflammatory cytokine IL-1beta in frequently ill children during the remission period].
Investigation of cytokines IL-1beta, INF-alpha and INF-gamma in frequently ill children in the period of remission was the main objective of the study. Two groups of children were investigated: a) 8 preschool children aged 4-6; b) 20 children aged 7-12. Interferon alpha and gamma were studied in the blood serum by Soloviov and Bektemirov method. IL-1beta was studied in the blood serum by hard phased immunoenzyme. Results were analysed by the computer program SPSS V 11.5. The patients were tested twice. During the first test indicators of interferon alpha and gamma were studied, and during the second test, performed within the 1-2 years time period, indicators of IL -1beta were added. It was found that the level of IL -1beta (p<0,05) was elevated.