Grand rounds: diagnostic use of autoantibodies in connective tissue diseases.
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Biomedical subjects
Publications and source records attributed to M V Waller.
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Elevated titers of serum agglutinators (anti-FabIgG) are associated with significant and severe suppurative infection. Immunosuppression and long-term antibiotic therapy, however, may lead to negative tests.
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Forty-four patients with high titers of anti-RNP antibodies, without anti-Sm or anti-nDNA antibodies, were studied retrospectively for clinical symptomatology, morbidity and mortality. Seven had died. Eleven had renal disease. Of patients with disease course greater than 7 years, only half had features of overlapping connective tissue diseases. The finding of high titer anti-RNP antibodies without anti-Sm or anti-nDNA did not appear to imply a distinct or unique clinical diagnosis or prognosis.