PubMed Health⌕ Search

Biomedical subjects

M V Zueva

Publications and source records attributed to M V Zueva.

33 records · Page 2Linked to original sources
PubMedDate not supplied

[Use of perindopril in the treatment of patients with diabetic retinopathy].

There have been recent data on an important role of the rennin-angiotensin system (RAS) and its major effector--angiotensin-converting enzyme (ACE) in the pathogenesis of diabetes mellitus and its complications. The treatment for diabetes mellitus with ACE inhibitors (ACEI) has received wide recognition. By lowering blood pressure, ACEI improves endothelial function, positively affect carbohydrate metabolism, and exerts a nephroprotective effect. However, the role of ACEI in the treatment of diabetic retinopathy (DR) remains to be studied. This paper presents the results of a comprehensive clinicofunctional study of 36 patients with preproliferative DR before and after treatment with the ACEI perindopril. The agent has been found to have a positive effect on visual functions, retinal electrogenesis, and the state of the blood-retinal barrier.

Adult↗
PubMedDate not supplied

[Topography and functional changes of the rabbit retina with a single injection of triamcinolone].

Intravitreal injections of 6 and 8 mg of triamcinolone (kenalog) were studied for impact on the time course of electroretinographic changes and the retinal structure of healthy rabbits. Histopathological study failed to reveal the signs of toxic damage to the retina. The electroretinographic findings suggest that kenalog primarily affect the function of photoreceptors and Muller's glia. The fact that the alteration of retinal functional activity may be linked with the early cytotoxic effects of the agent cannot be ruled out. However, the changes found in retinal electrogenesis are most likely to reflect the mechanisms of kenalog's beneficial therapeutic action that is primarily mediated through its effect on the function of photoreceptors and Muller's cells.

Animals↗
PubMedDate not supplied

[Effect of enkad on the development of experimental chloroquine retinopathy].

The effect of enkad on the development of chloroquine retinopathy in rabbits was studied by electron microscopy and electrophysiological methods. It is shown that subconjunctival enkade injection inhibits the development of a dystrophic process in the retina induced by intravitreous chloroquine administration.

Animals↗
PubMedDate not supplied

[Prediction of functional results of extraction in complicated cataract in patients with tapetoretinal abiotrophy].

Relative informative value of various functional methods of investigation was studied in 87 patients with tapetoretinal abiotrophy and complicated cataracts in order to find adequate methods for the assessment of the retinal status before surgery and to define the criteria of visual function prediction. The efficacy of the diagnosis was verified after cataract extraction in these patients. The methods of investigation employed were instrumental electroretinogram (ERG) recording, Hanz-Feld stimulated microERG, high-frequency (40 Hz) rhythmic ERG, electrocoagulograms, determination of electric sensitivity thresholds for the retina and of the optic nerve axial bundle lability (ESL), perimetry, and vision acuity measurements. Rhythmic ERG and ESL were found the most informative; rhythmic ERG amplitude proved to be the most sensitive to macular area involvement, this prompting employment of this method for the prediction of visual functions. Rhythmic ERG helped single out three groups of patients with relatively favorable, doubtful, and unfavorable outcomes.

Cataract↗
PubMedDate not supplied

[Pathological changes in the eyeball in tapetoretinal abiotrophy].

The authors sum up the results of comprehensive examination of all the principal structures of the eyeball in patients with tapetoretinal abiotrophy. Present-day methods of investigation were employed, that helped reveal a generalized pattern of the pathologic process in this condition. The detected shifts should be borne in mind when choosing a method for cataract extraction in such patients.

Adult↗
PubMedDate not supplied

[Spectral characteristics of intraocular lenses and injury to the retina caused by visible light].

It has been shown that intraocular lenses (IOL) prepared from polymethylmethacrylate and silicon let pass the light of short-wave visible and long-wave spectrum regions. Unlike natural lens, IOL have no yellowish coloration, which results in the appearance of chromatic aberrations and brightness of IOL during implantation. Mechanisms of damaging effects of visible light on the retina were studied. It has been shown that a week after the rat eyes were illuminated the waves "a" and "b" ERG were inhibited. At the ultrastructural level damage of the cells of the retinal pigment epithelium and of the retinal layers formed by photoreceptor cells took place. Dynamics of the damage of tissue structures of the retina by visible light was investigated. It is suggested that application of colored lenses and prophylaxis by the inhibitors of free radical oxidation will protect the retina from photochemical damage.

Animals↗
PubMedDate not supplied

[Manifestations of immunopathology and validation of immunotherapy of diabetic retinopathy].

Three-year clinical and immunological studies of 378 patients with diabetic retinopathy revealed involvement of the T- and B-immunity systems and the specific features of the local autoimmune response to the retinal S-antigen, which manifest during the early preclinical stage of diabetic retinopathy. The progress of retinopathy is associated with augmenting insufficiency of T-suppressors, inhibition of lymphocyte blastogenesis with phytohemagglutinin, and an increase in the levels of B-lymphocytes, IgM, and circulating immune complexes in the blood. Two abnormalities of autoimmune response of the eye to S-antigen were observed in patients with the proliferative forms: hypersensitivity and insufficiency of the immune response. A moderate level of S-antigen in tears is a protective factor, stabilizing retinopathy. The authors validate the significance of immunological test for predicting the course of retinopathy and emphasize the differentiated approach to local and total-system's correction of immune disorders in diabetics.

Adolescent↗
PubMedDate not supplied

[Restoration of retinal functional activity after surgical treatment of its detachment in patients with different eyeball injuries].

Nineteen case histories are analyzed: 1) 6 patients with postperforative detachment of the retina; 2) 8 patients with detachment of the retina after a penetrating wound with introduction of a foreign body; and 3) 6 patients with postcontusion detachment. The restoration of the alpha and beta ERG waves depended on the type of injury: after penetrating wounds, the changes in the retinal electrogenesis were the most manifest during the initial and early postoperative period; foreign bodies aggravated and decelerated the regeneration of visual function, contusion trauma of the eye is the most unfavorable factor complicating the restoration of visual functions; involvement of the paired (intact) eye is typical, as is changed functional reaction of the retina in injuries of all types.

Electroretinography↗
PubMedDate not supplied

[Impairment of visual pathway function in right hemisphere in patients with arteriovenous malformation of the parietooccipital area of left hemisphere].

Marked arteriovenous malformation in the left parietooccipital area manifested only by symptoms of associative migraine involving changes of visual fields indicative of impaired functions of symmetrical compartments of the other brain hemisphere. Visual evoked potentials were changed in this patient because of dysfunction of both hemispheres and largely because of disorders in brain structures symmetrical to the site of arteriovenous malformation. This can be regarded as a manifestation of the so-called stealing phenomenon, when blood supply to one brain compartment is decreased because of excessive blood delivery to other regions of the brain. The results permit us to hypothesize regulation of blood supply to symmetrical compartments of brain hemispheres.

Cerebral Angiography↗