PubMed Health⌕ Search

Biomedical subjects

M V de Silva

Publications and source records attributed to M V de Silva.

At least 19 recordsLinked to original sources
PubMed2001

Body stalk anomaly.

Explore the source record for details and available documents.

Abdominal Muscles↗
PubMed2000

Comparison of some clinical and histological features of colorectal carcinoma occurring in patients below and above 40 years.

OBJECTIVE: To determine the clinicopathological features of colorectal malignancies in Sri Lankan patients aged 40 years or younger, and to compare them with those of older patients. METHODS: The clinicopathological features of 60 colorectal malignancies which occurred in patients aged 40 years or younger were compared with 245 malignant colorectal tumours in older patients. These tumours had been diagnosed at a University Department of Pathology over 15 years. RESULTS: 19.7% of colorectal malignancies occurred in patients aged 40 years or younger. (Male:Female ratio = 1.6:1). The mean duration from onset of symptoms to diagnosis was 4.2 months. There was no statistically significant difference between young and old patients in the presenting symptoms, site of tumour and Dukes' staging of colorectal malignancies. A statistically significant proportion of tumours in young patients was mucoid (13.3%) or signet ring cell (5%) type. 3.3% of young patients with colorectal carcinoma gave a family history of similar malignancy. A history of predisposing conditions (ulcerative colitis) was present in 3.3% of young patients. CONCLUSIONS: The clinical presentation of colorectal malignancies in Sri Lankan patients below 40 years of age does not differ from that in older patients. Mucoid and signet ring cell carcinomas are commoner in the young.

Adult↗
PubMed2000

Extensive intraduct component in invasive duct carcinoma of the breast: prevalence and significance in a south Asian setting.

Extensive intraduct component (EIC) in invasive duct carcinoma is one of the main factors affecting local cancer recurrence and thereby a major consideration in breast conserving therapy. A retrospective study was undertaken to assess the prevalence of extensive intraductal component in a South Asian setting. 105 cases of invasive duct carcinoma reported at a University Pathology Department during a 75 month period from January 1992, were reviewed. 48.6 percent of all cases assessed had an intraductal component. 13.3 percent had an EIC. Of the seventy-two T1 and T2 tumours reviewed 5.6 percent showed EIC. The results of this study indicate that by virtue of its low prevalence. EIC in infiltrating ductal cancer is unlikely to be a major obstacle in the decision of breast conserving therapy in the South Asian region.

Breast Neoplasms↗
PubMed2000

Increase in information content in histopathology reports: a concealed workload for histopathologists.

INTRODUCTION: The workload of histopathologists is traditionally assessed by the total number of specimens handled annually (TSA). Development in medical science has resulted in an increased demand by clinicians for more information in histopathology reports. Inclusion of this information requires more work. Annual information output (AIO) is the total number of specimens handled annually multiplied by the average number of items of information per histopathology report (AIR). An item of information is any pathological feature of prognostic or therapeutic relevance. OBJECTIVE: This study aims to determine whether there has been an increase in annual information output (AIO) during a 17-year period. METHOD: This is a retrospective study in a University Department of Pathology. 200 histopathology reports per year at 4 yearly intervals from 1982 to 1998 were examined. TSA, AIR and AIO were calculated. RESULTS: TSA increased from 2912 in 1982 to 3919 in 1998 (34.6% increase). AIR increased from 1.11 to 3.12 (181.1% increase). AIO increased from 3232.3 to 12227.3 (278.3% increase). CONCLUSION: The increase in AIO was greater than the increase in TSA. Thus the use of TSA alone will not reflect the increase in workload accurately. We recommend the use of AIO rather than TSA to quantify workload and staffing requirements of histopathologists.

Forms and Records Control↗
PubMed1999

Breast cancer: do histopathology reports provide adequate information for patient care?

INTRODUCTION: Many studies have shown that certain pathologic features correlate with risk of recurrence, development of nodal and distant metastases, long term survival and multicentricity of breast carcinoma. Such information is useful in selection of appropriate therapy and prognostication. OBJECTIVE: To determine the proportion of histopathology reports of breast carcinoma that provide essential pathologic prognostic information. METHOD: All (110 mastectomy and 25 lumpectomy) cases of breast carcinoma reported during 79-month period from January 1992 were assessed for inclusion of tumour size, information on excision margins and 8 microscopic features. Mastectomy reports were evaluated for information on axillary lymph node status. RESULTS: 9.6% of reports assessed included all relevant features. All 110 mastectomy reports gave information on axillary lymph node status. Tumour size was included in 91.1% of reports. Excision margins were commented on in 36% of lumpectomy reports. Of the microscopic features assessed, tumour type was included in 98.5% and histologic grade in 66.7%. In formation on other features ranged from 28.1% for inflammatory infiltrate at the tumour-host interface to 69.1% for nipple invasion. CONCLUSION: Reporting on basic prognostic information falls short of the ideal. Provision of guidelines will help to ensure the inclusion of relevant histopathologic prognostic information.

Breast Neoplasms↗
PubMed1998

A single pathological grading system for breast carcinoma should be adopted in Sri Lanka.

INTRODUCTION: Histologic grading of breast cancer is related to prognosis and management of patients. The grading systems used are the initially formulated subjective methods, and the more recently described objective Nottingham system. In Sri Lanka there is lack of uniformity in histopathology reporting of breast cancer. All methods used employ 3 grades. If histologic grading is to be of clinical relevance, it is important that the grades of different systems correlate with one another. OBJECTIVE: To determine if the three grades of the Nottingham system correlate with those of the other systems. SETTING: Department of Pathology, Faculty of Medicine, Colombo. METHOD: 54 breast carcinomas were graded using the Nottingham system by reviewing histology slides. The Nottingham grading was compared with the original grading mentioned in the histology report. RESULTS: The original reports included 35 tumours graded with systems other than Nottingham. 45.7% of these tumours did not correspond with the subsequent Nottingham grade. 40% had to be upgraded from grade II to III. When the 19 tumours originally graded using the Nottingham system were re-evaluated using the same system, there was concurrence in 89.5% of the cases. CONCLUSION: Our results indicate a failure of other grading systems to correlate with the corresponding Nottingham grade in a high proportion of cases. We recommend the adoption of a single, objective grading system such as the Nottingham method by all clinicians in Sri Lanka.

Breast Neoplasms↗
PubMed1998

Prevalence of prostatic intraepithelial (PIN) in surgical resections.

OBJECTIVES: To determine the prevalence of prostatic intraepithelial neoplasia (PIN) in surgical specimens and assess its relationship to adenocarcinoma. METHOD: 205 surgical specimens (191) transurethral resections, 6 open prostatectomies, 8 needle biopsies) reported at the University Department of Pathology, Colombo over 64 months were reviewed. RESULTS: There were 170 benign hyperplasias and 35 adenocarcinomas. PIN I was present in 22.92% PIN II in 5.36% and PIN III in 7.32% of the specimens. 8.51%, 27.27% and 93.3% PIN I, PIN II and III were associated with invasive adenocarcinoma. Nine cases (4.39%) had high grade PIN (PIN II & III) in the absence of adenocarcinoma. CONCLUSION: PIN II & III were strongly associated with coexistent carcinoma but PIN I was not. The finding of high grade PIN in surgical biopsies with no obvious adenocarcinoma warrants examination of all available tissue and deep sections.

Adenocarcinoma↗
PubMed1998

Obstetric performance, perinatal outcome and risk of infection to the newborn in spontaneous and artificial rupture of membranes during labour.

OBJECTIVE: To compare the obstetric performance, perinatal outcome and risk of neonatal infection in labour following spontaneous (SROM) and artificial (AROM) rupture of membranes. DESIGN: Prospective, non-randomised, comparative study during a one-month period in 1995. The study was approved by the ethics committee of the Faculty of Medicine, University of Colombo. SETTING: University Obstetrics Unit at De Soysa Hospital for Women, Colombo. PATIENTS: 324 women who were in early established labour after 37 weeks of gestation. 151 of these had SROM and 173 AROM. The AROM and SROM groups among primigravidae and multigravidae were considered separately. RESULTS: Oxytocin use in multigravidae was significantly higher in the AROM group than in the SROM group (p < 0.001). The emergency caesarean section (LSCS) rate in primigravidae was significantly higher in the AROM group than the SROM group (p < 0.001). A significantly larger number of primigravid AROM women had abnormal fetal heart rate changes on auscultation (p < 0.05) and cardiotopographic (CTG) patterns (p < 0.001) when compared with primigravid SROM women. Choreoamnionitis and funisitis were commoner in the AROM group although the difference was not statistically significant. CONCLUSIONS: AROM appears to be associated with a higher chance of fetal distress particularly in primigravidae. Both AROM and SROM are associated with a potential risk of infection at intrauterine sites.

Adult↗