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Biomedical subjects

M Valen

Publications and source records attributed to M Valen.

6 recordsLinked to original sources
PubMed2004

Reduced joint pain after short-term duodenal administration of seal oil in patients with inflammatory bowel disease: comparison with soy oil.

BACKGROUND: Rheumatic joint pain is a common extra-intestinal complication of inflammatory bowel disease (IBD). Because the high ratio of n-6 to n-3 fatty acids (FAs) of the Western diet might promote rheumatic disorders, we sought to compare the effects of short-term duodenal administration of n-3-rich seal oil and n-6-rich soy oil on IBD-related joint pain. METHODS: Nineteen patients with IBD-related joint pain were included in the study; 9 had Crohn disease and 10 had ulcerative colitis. Ten millilitres seal oil (n = 10) or soy oil (n = 9) was self-administered through a nasoduodenal feeding tube 3 times daily for 10 days. RESULTS: Compared with soy oil treatment, seal oil significantly reduced the duration of morning stiffness (P = 0.024), number of tender joints (P = 0.035), intensity of pain (P = 0.025) and the doctor's scoring of rheumatic disease activity (P = 0.025) at the end of the 10-day treatment period. Analysis of the effects as area under the curve (area between the curve and baseline, zero) for the entire period from start of treatment until 6 months' post-treatment suggested a long-lasting beneficial effect of seal oil administration on joint pain, whereas soy oil tended (not significantly) to aggravate the condition. Consistently, the serum ratios of n-6 to n-3 FAs (P < 0.01) and arachidonic acid to eicosapentaenoic acid (P < 0.01) were reduced after treatment with seal oil. CONCLUSION: The results suggest distinctive, differential prolonged effects on IBD-related joint pain of short-term duodenal administration of n-3-rich seal oil (significant improvement) and n-6-rich soy oil (tendency to exacerbation).

Adolescent↗
PubMed2000

LaminOss immediate-load implants: I. Introducing osteocompression in dentistry.

Osteocompression is a physiologic principle that has been clinically practiced in orthopedics since the early 1900s. In dentistry, controlled functional osteocompression is the compaction created by the tapping procedure and bone lamination achieved by a sinusoidal screw implant design providing physiologic stimulation due to streaming potentials. Functionally, there is always an applied force acting on bone modified by an implant design, and there is always a resisting force acting on the implant through the viscoelastic properties of trabecular structure. Through biomechanical events in bone, osseous tissue can be stimulated within physiologic limitations by implant design to develop along the lines of compressive forces dependent on the implant load-bearing area to sustain equilibrium. At the cellular level, these biomechanical events act on the cells through a phenomenon known as streaming potentials. This is an electrochemical potential created by the flow of extracellular fluid past a positively charged cell surface. Streaming potentials have a stimulating effect on osteoblasts and osteocytes. This stimulation under acceptable physiologic limits translates to an ordered deposition of osseous tissue that aids in the support of these compressive forces. As a sinusoidal thread design, the LaminOss osteocompressive immediate-load implant (Impladent Ltd, Holliswood, NY) has shown in animal histologic observation 2.5 times greater bone lamination achieved by the function of osteocompression due to the benefits of streaming potentials created by the LaminOss implant design. No evidence of bone necrosis was observed by any of the eight implants.

Alveolar Process↗
PubMed2000

LaminOss immediate-load implants: II. Clinical considerations of osteocompression.

The sinusoidal thread design of the LaminOss (Impladent Ltd, Holliswood, NY) osteocompressive immediate-load implant is structured with minimal shear interface to function in horizontal planes and stimulate bone growth by the action of streaming potentials at the implant thread surface area. This implant design, when used with a unique surgical instrumentation technique, allows maximum bone to be molded and compacted circumferentially around the sinusoidal implant threads. The surgical technique of bone lamination around larger implant horizontal planes (or load-bearing areas) creates a stable foundation for placing this implant into immediate function. For the past 10 years this surgical procedure has provided patients with immediate function the day of implant placement. The clinical advantage of immediate implant loading enhances care acceptance and patient satisfaction.

Bite Force↗
PubMed1990

Establishment of an implant selection protocol for predetermined success.

Previously, implant selection was confined to radiographs and to plastic implant templates for evaluation of existing bone. The aim of this study was to determine implant support areas in a compressive mode and to establish a standard via an implant selection protocol. Successful implant selection, regardless of the device design, is relevant to a patient's muscular efficiency and implant support values based on bone quality and size of prescribed bridge. The compressive areas of support, in mm2, of 15 implant designs were computer-analyzed and graph-evaluated. Major/minor diameters and the lengths of screws and cylindrical types of devices were calculated. In addition, the length, width, vents, and any lateral support areas of blade types were recorded. Average muscular force data, provided by clinical transducer studies, and literature reports of the mechanical properties of trabecular bone were correlated with computer bone analyses. These studies determined the quality of maxillary and mandibular bone to be 10 MPa and 15 MPa, respectively. Results indicated that four-unit bridges, at 50 lbs of applied force, require an area 31.14 mm2 of implant support in a compressive mode in the maxilla, and a support area of 20.76 mm2 in the mandible. Five-unit bridges require 40.84 mm2 in the maxilla and 27.23 mm2 for the mandible, because of the moment force, or torque, on the implant. Findings indicated that by determining: (1) the patient's muscular efficiency at implant sites (quantifying dynamic values of the forces and moments on implants supporting functioning bridges); (2) implant support values based on the compressive strength of the cancellous bone at implant sites; and (3) the size of the prescribed bridge, it is possible for the success (or failure) of a selected implant to be predetermined.

Alveolar Process↗
PubMedDate not supplied

Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs.

OBJECTIVE: To investigate the presence of oral bacterial DNAs in serum and synovial fluid (SF) of patients with active rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS: Serum and SF samples from 16 RA patients, 14 PsA patients, and 9 osteoarthritis (controls) patients were extracted for oral bacterial DNA. This was used in a checkerboard DNA-DNA-hybridization set up, to identify 40 different bacteria. RESULTS: Mean number +/- standard deviation (SD) of oral bacterial species in sera were 6.2 (3.2) in the RA group (p = 0.004) and 5.4 (2.7) in the PsA group (p = 0.009) compared to 2.1 (1.7) in the controls. Periodontitis associated species Porphyromonas gingivalis and Prevotella nigrescens were exclusively detected in RA and PsA. Mean number (+/- SD) of oral bacterial species in SF were 14.0 (6.8) in the RA (p = 0.001) and 19.4 (7.1) in the PsA group (p < 0.001) compared to 4.0 (1.7) in controls. P. gingivalis, Tannerella forsythensis and Prevotella intermedia were exclusively identified in RA and PsA SF. Higher means of DNAs were found in RA SF compared to RA serum (p < 0.001), and in PsA SF compared to PsA serum (p < 0.001). Higher concentrations of bacterial DNAs were found in RA and PsA compared to controls. CONCLUSION: Higher variety and concentrations of oral bacterial DNAs were found in SF compared to serum of RA and PsA patients. These findings indicate that synovial inflammation in RA and PsA may favor trapping of oral bacterial DNAs, suggesting a perpetuating effect of oral pathogens in joint disease.

Adult↗