Biomedical subjects
Publications and source records attributed to M Vanbockrijck.
We present a case of concurrence of ectopic adrenal cortex with a renal cell carcinoma. The diagnosis of the accessory adrenal tissue was made by CT-guided biopsy. With this case report, we draw attention to a specific differential diagnostic problem, policy and to the MR characteristics of ectopic adrenal cortex.
Patients with a history of gastroduodenal surgery for benign lesions are at increased risk of developing cancer of the gastric stump. The majority of malignant tumors arising in gastric remnants are adenocarcinomas, but a few of cases of malignant lymphoma have been reported as well. Some recent studies have suggested that Helicobacter pylori-associated gastritis may play a role in the pathogenesis of primary gastric lymphoma. We report a case of primary high grade polymorphic B-cell lymphoma (high grade MALT lymphoma) occurring in the gastric stump of a 74-year-old man 17 years after Billroth-II gastrectomy. The non-tumorous gastric mucosa showed features of reflux gastritis with presence of deeply situated dense lymphoid aggregates in the lamina propria. However, no micro-organisms with the morphology of Helicobacter pylori could be found at the luminal surface. The literature concerning gastric stump lymphomas is reviewed.
BACKGROUND: Primary gastrointestinal lymphoma currently is considered to be an uncommon complication of chronic inflammatory bowel disease. All tumors reported in which recently developed techniques, such as immunohistochemical markers, were used for lymphoma classification proved to be non-Hodgkin lymphomas. Gastrointestinal lymphomas developing in Crohn disease are a very heterogeneous group, with tumors of both B-cell and T-cell lineage represented, along with some tumors of equivocal phenotype. By contrast, gastrointestinal lymphomas complicating ulcerative colitis all have proved to be so-called polymorphic B-cell lymphomas. METHODS: The current report describes another case of primary gastrointestinal lymphoma complicating chronic inflammatory bowel disease occurring in the ileum of a 34-year-old man with a 3-year history of Crohn disease. RESULTS: Histopathologic findings were in keeping with nodular sclerosing Hodgkin disease. Broad birefringent collagen bands divided the tumor into well-defined nodules consisting of typical Reed-Sternberg cells and lacunar variants admixed with a polymorphous lymphoid infiltrate. By immunohistochemical studies, Reed-Sternberg cells and lacunar variants stained positively for Leu-M1 (CD15) and Ber H2 (CD30). The background lymphocytes were primarily of T-cell phenotype. CONCLUSIONS: To the knowledge of the authors, this article reports the first case of primary gastrointestinal Hodgkin disease in association with chronic inflammatory bowel disease that has been confirmed by immunohistochemical studies.
Incidence and morphologic pattern of liver metastasis from extrahepatic cancer in cirrhosis were studied in 2162 consecutive autopsies performed during a 12.5 year period. The cirrhotic liver was less frequently affected by metastasis than the noncirrhotic liver (33.3% versus 46.4%). The incidence of extrahepatic malignancies and their hematogenous metastasis was lower (though statistically not significant) in patients with cirrhosis than in patients without cirrhosis (20% versus 32%). Patients with cirrhosis but without cancer died at a younger age (63.5 years) than patients with both cancer and cirrhosis (69.5 years). In cirrhotic livers, metastases from neuroendocrine tumors were predominantly localized within the parenchymal nodules, while nonendocrine carcinomas metastasized to the fibrotic septa. The results suggest (1) that patients with cirrhosis develop less frequently extrahepatic malignancies and hepatic metastasis than patients without cirrhosis, probably because of a shorter life expectancy due to the complications of liver cirrhosis; (2) microscopic localization of metastases in cirrhotic livers depend on tumor type.