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Biomedical subjects

M Varga

Publications and source records attributed to M Varga.

At least 19 recordsLinked to original sources
PubMed1992

[Noninvasive imaging of the proximal coronary arteries by transesophageal echocardiography].

Authors give an account of their experiences about the visualization of the proximal coronary arteries on the basis of the transesophageal echocardiographic examination of 45 patients. According to their observations the left main coronary artery, the bifurcation, the left anterior descending artery and the circumflex coronary artery were well visualized in 40 patients. With the help of pulsed Doppler-echocardiography the Doppler flow velocity spectrum of the coronary flow can be detected, which could be analysed in 25 patients. At the same time the visualization of the right coronary artery is less sensitive, valuable images could be detected only in 12 patients. The technique of the TEE visualization of the proximal coronary arteries is described. TEE seems to be a promising approach to the morphologic evaluation of the proximal coronary arteries and for functional pathophysiologic examinations of coronary blood-flow.

Coronary Circulation↗
PubMed1992

A suicidal death by explosives.

A 23-year-old man committed suicide by detonating an explosive substance clutched to his abdomen. The face was singed, the hands were lacerated and the chest and the upper part of abdomen were badly mutilated. The death was due to the destruction of several vital organs. The injuries had a directional nature. Only the consideration of all the facts of the case in relation to the situation, nature, distribution and extent of wounds and the preceding medical and social history allowed a reconstruction of the circumstances.

Abdominal Injuries↗
PubMed1992

Understanding the role of oxyradicals in general and in toxic hepatic damage can help safer drug design.

The existence and importance of free radicals are well established both theoretically and in in vivo experiments. Methods and techniques are now available to demonstrate the formation of free radical metabolites of natural substances and xenobiotics. Theories of the biological effects of free radicals could be unified and used for a better understanding of the complex processes of the organism. Pharmacology can gain profit from this multidisciplinary approach, which helps to design safer drugs. The theories of free radicals and the results of experiments with antioxidants could help to decrease the oxidative stress caused by pharmaceutical chemicals.

Animals↗
PubMed1992

Change of alcohol dehydrogenase activity in sera after alcoholism treatment.

Increased metabolic alcohol tolerance was found in chronic non-cirrhotic alcoholics after alcoholism treatment with disulfiram. This increased metabolic alcohol tolerance is connected with an increased activity of alcohol dehydrogenase due to the healing of hepatic tissue damage. This increase in alcohol dehydrogenase activity can help in monitoring the effectiveness of treatments for alcoholic liver disease.

Adult↗
PubMed1991

[Malignant B-cell lymphoma in a patient with primary Sjögren syndrome].

Authors report the case of a 42 years old female with primary Sjögren's syndrome in whom nine years after the beginning of her disease generalised swollen lymphatic nodes and enlargement of liver as well as a spleen has appeared. The simultaneous appearance of fever, loss of body weight and worsening of her general condition raised the possibility of an associated malignant lymphoproliferate disease. The histology of a lymph node proved the presence of a highly malignant form of B-cell lymphoma (CB NHL). Attention is drawn to the necessitate of regular control of patients with Sjögren's syndrome. Lymphadenopathy, the decrease of the immunoglobulin levels and autoantibody titer in the serum, as well as the predominance of monoclonal immunoglobulins point to the possibility of malignant transformation. With reference to the presented case a short review of the Sjögren's syndrome is given by the authors.

Adult↗
PubMed1991

How can free radicals cause damage to hepatic cells. A multidisciplinary approach.

Excessive alcohol intake is a factor in a significant percentage of all deaths. Hepatoprotective drugs aim to prevent alcoholic liver damage. Our experiments with antioxidant free radical scavengers also proved that such chemicals are hepatoprotectives. Free radical reactions play a significant role in many biological phenomena such as aging and toxic liver cell damage. Different disciplines support theories to interpret their effects. In this paper, theories are summarized as a multidisciplinary approach which can provide further explanation and challenge further investigation on alcoholic liver damage and hepatoprotection.

Animals↗
PubMed1991

Assessment of cognitive impairment: the role of CT.

The value of CT as a routine screening procedure in the investigation of cognitive impairment is being increasingly challenged. To address this issue, we reviewed the records of 175 patients with intellectual deficits admitted to a Behavioural Neurology Unit over a two-year period. In the vast majority of cases, ie. 82%, the CT served essentially to confirm the clinical impression and added no new diagnostic information that impacted the management of the presenting problem. In 15% of cases the CT scan was helpful for diagnosis, especially in the differentiation between Alzheimer's disease and multi-infarct dementia.

Adult↗
PubMed1991

Radiographic personal identification with characteristic features in the hip joint.

This case demonstrates a radiographic personal identification. A body was found but no positive results were obtained from the remains regarding the cause of death, the manner of death, or precise identification. At the autopsy, a characteristic radiographic deformity was found in the hip joints. After searching the registry of persons with congenital acetabular dysplasia and super-imposing the postmortem radiograph on the films of the registry, the identification was successful.

Adolescent↗
PubMed1991

Ethanol elimination in man under influence of hepatoprotective silibinin.

The effect of a single dose of hepatoprotective silibinin on blood alcohol elimination was investigated. Neither influence on the blood alcohol curve, nor detectable increase in the beta 60 value was found, although biochemical considerations suggest such an effect. Though silibinin has a protective effect on chronic alcohol liver injury, it does not influence acute alcohol elimination, and is therefore not suitable for use as a "sobering-up" agent.

Adult↗
PubMed1990

Quantitative ultrastructural analysis of hepatoprotective effects of (+)-cyanidanol-3 on alcoholic liver damage.

Biochemical considerations suggest that bioflavonoids may be effective antihepatotoxic and hepatoprotective agents. We, therefore, designed a morphometric study to examine the effect of (+)-cyanidanol-3 on ethanol-induced hepatocellular alterations. Using a stereologic point and intersection counting method we determined the volume fraction of cytoplasmic components, the surface area of cytoplasmic membranes, some parameters of mitochondria, and numerical densities of some organelles, after chronic ethanol intoxication and hepato-protective treatment of rats. Consistent with previous qualitative and quantitative descriptions, chronic ethanol feeding caused increases in parameters of mitochondria, microsome, and Golgi complex. The hepatoprotective (+)-cyanidanol-3 treatment restored most of the morphologic distortion caused by ethanol ingestion. The (+)-cyanidanol-3 treatment alone caused an elevation of the surface area of smooth endoplasmic reticulum and nonsignificant changes in mitochondrial parameters, possibly due to its inducing effect on microsomes and activating effect on mitochondrial enzymes. These data indicate that bioflavonoids could be of potential benefit in hepatotoxic or alcohol-related liver disease.

Animals↗
PubMed1990

Effect of a novel soft steroid on the wound healing of rabbit cornea.

The effect of a 'soft' anti-inflammatory corticosteroid on the corneal wound healing was investigated in rabbits. Albino rabbits were treated with soft steroid and dexamethasone after linear perforating corneal incision. Soft drug design is aimed to control and direct the drug activity and in vivo metabolism to nontoxic moieties. These drugs are rapidly deactivated after they reach the general circulation. While having good local activity, they thus possess high therapeutic indexes without systemic side effects. The wound healing process was evaluated qualitatively by histology. Photomicrographs are presented to show that the soft steroid is as or more effective than dexamethasone in minimizing scarring in addition to its advantageous metabolic properties. This soft steroid may be an efficient anti-inflammatory and anti-allergic agent in topical application without the majority of unwanted activities of traditional drugs by deliberately simplifying their disposition.

Androstadienes↗
PubMed1990

[Direct measurement of the pulling force affecting the flexor tendons of the hand].

A thought, returning again and again in hand surgery, is the immediate introduction of active motion therapy after the reconstructive operations of the flexor tendons. To the active motion an adequately strong tendon suture, to the definition of "adequately strong tendon suture" however the measurement of the pulling force, acting actually on the flexor tendons is necessary. Authors attempted to measure this pulling force during flexor tendon operations on cadaver's hand. On the basis of their measurements the maximal pulling force, that can be expected during postoperative active movement exercises with adequate circumspection, can be estimated as two kiloponds.

Exercise Therapy↗
PubMed1990

[Discoid lupus erythematosus beginning on the eyelids].

We report on a 20-year-old women, who suffered from discoid lupus erythematosus (DLE) beginning on her eyelids with dyschromia and cutaneous infiltration. Similar signs appeared on the top of her nose, her nostrils, and her lower lip. Simultaneously with these alterations, we found a superficial exulceration on her hard palate, which histologically proved typical for DLE. After therapy with chloroquine for 3 weeks, the alterations disappeared.

Adolescent↗
PubMed1990

[Measurement of the tensile force exerted on the flexor tendons of the hand].

Immediate postoperative active motion after flexor tendon repair is a recurring theme in hand surgery. In the present study the authors determined the tensile stress of the sutured tendon subjected to active motion by the use of cadaveric hands and a tensiometer. The force necessary to draw forth the proximal stump was also measured. A tendon suture which can resist two kilo-ponds tensile force seems to allow active motion of the reconstructed flexor tendon.

Exercise Therapy↗
PubMed1990

[Variabilities of kinetics of alcohol catabolism].

The resorption, distribution and elimination of ethanol vary individually. The differences in the resorption deficit and elimination coefficient can be of great extent. Though the generally accepted average of resorption deficit is 20%, which is calculated with in forensic practice, this value can occasionally be a lot higher. The elimination coefficient (beta value) depends on the blood alcohol level. Beta value was found higher than 0.15%o/h, the generally accepted one, even below 1.5% blood alcohol content, above 2.5% the beta value was found to be as high as 0.33%o h. This faster rate of ethanol clearance is due to induction of alcohol elimination systems. The ethanol metabolism at higher blood alcohol levels is characterized by Michaelis-Menten kinetics.

Alcohol Drinking↗
PubMed1989

A case of Churg-Strauss syndrome.

A 54-year-old woman died after being battered, but the forensic autopsy revealed that her injuries were not serious or lethal. A detailed histological examination revealed that the basic disease had been Churg-Strauss syndrome. The differentiation of this syndrome of pulmonary infiltration and eosinophilia (PIE syndrome) from other allergic and noninfectious granulomatoses needs cautions consideration.

Churg-Strauss Syndrome↗
PubMed1989

The effect of timolol, betaxolol and levobunolol on the surface of rabbit cornea.

Pigmented rabbits were treated with timolol maleate, betaxolol hydrochloride or levobunolol hydrochloride eye drops twice a day for six months. Animals of the same age group and breed were used as controls. There were no differences observed in corneal epithelium with light and transmission electron microscopy. With scanning electron microscopy, in the timolol and betaxolol treated animals the picture of the corneal surface was similar to that of normal rabbit corneas after exposure to air. In scanning electron micrographs of the levobunolol treated animals, the corneal surface resembled the corneas of normal rabbits treated with artificial tears.

Administration, Topical↗